ArticleThe EMBO journal1991
The late retinoic acid induction of laminin B1 gene transcription involves RAR binding to the responsive element.
Article in The EMBO journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 152 citations in OpenAlex.
- Cingulate retinoic acid signaling regulates neuropathic pain and comorbid anxiodepression via extracellular matrix homeostasis.The Journal of clinical investigation · 2025Article
- Retinoids in the Pathogenesis and Treatment of Liver Diseases.Nutrients · 2022Review
- Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism.International journal of molecular sciences · 2015Review
- The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.BMC molecular biology · 2010Article
- All-trans retinoic acid suppresses exocrine differentiation and branching morphogenesis in the embryonic pancreas.Differentiation; research in biological diversity · 2007Article
- Retinoic acid receptor-mediated induction of ABCA1 in macrophages.Molecular and cellular biology · 2003Article
- Evidence for defective retinoid transport and function in late onset Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2003Review
- Mouse retinol binding protein gene: cloning, expression and regulation by retinoic acid.Molecular and cellular biochemistry · 2000Article
- Oncogenic regulation and function of keratins 8 and 18.Cancer metastasis reviews · 1996Review
- Isolation of a novel retinoic acid-responsive gene by selection of genomic fragments derived from CpG-island-enriched DNA.Molecular and cellular biology · 1996Article
- Positive elements in the laminin gamma 1 gene synergize to activate high level transcription during cellular differentiation.Nucleic acids research · 1996Article
- Positive regulation of the vHNF1 promoter by the orphan receptors COUP-TF1/Ear3 and COUP-TFII/Arp1.Molecular and cellular biology · 1996Article
- An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Widely spaced, directly repeated PuGGTCA elements act as promiscuous enhancers for different classes of nuclear receptors.Molecular and cellular biology · 1995Article
- Tissue-specific distribution of a novel C-terminal truncation retinoic acid receptor mutant which acts as a negative repressor in a promoter- and cell-type-specific manner.Molecular and cellular biology · 1995Article
- Targeted disruption of retinoic acid receptor alpha (RAR alpha) and RAR gamma results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism.Molecular and cellular biology · 1995Article
- AP-1, ETS, and transcriptional silencers regulate retinoic acid-dependent induction of keratin 18 in embryonic cells.Molecular and cellular biology · 1994Article
- Cryptic promoter activity within the backbone of a plasmid commonly used to prepare promoter/reporter gene constructs.In vitro cellular & developmental biology. Animal · 1994Article
- Regulation of the Oct-4 gene by nuclear receptors.Nucleic acids research · 1994Article
- Homo- and heterodimers of the retinoid X receptor (RXR) activated transcription in yeast.Nucleic acids research · 1994Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Transcription of the murine laminin B1 (LB1) gene is induced by retinoic acid (RA), but responds only 24-28 h after RA treatment in F9 EC cells. Here we have shown by gel retardation assay that all three retinoic acid receptors (RARs) alpha, beta and gamma expressed in Cos cells can bind directly to the previously characterized retinoic acid response element (RARE) of the LB1 promoter, albeit with a weaker affinity than to the RAR-beta gene RARE. Three stereo-aligned TGACC-like motifs are crucial for this binding. Interestingly, the capacity of RAR-alpha, -beta and -gamma to bind the LB1 RARE appears to be differentially modulated by factor(s) present in HeLa cells infected with RAR-expressing vaccinia virus vectors. Analyses of LB1 RARE mutants provide a strong correlation between RA-inducibility in vivo and efficiency of RAR binding in vitro. Thus, RARs can participate directly in transcriptional induction of the LB1 gene, even though this induction is cycloheximide sensitive and RARs are present in F9 cells prior to RA addition.
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