ArticleMagnetic resonance in medicine2008
MagA is sufficient for producing magnetic nanoparticles in mammalian cells, making it an MRI reporter.
Article in Magnetic resonance in medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
101 citing papers in PubMed, 180 citations in OpenAlex.
- Review
- Advances in iron-storage protein-based MRI reporter genes: from molecular mechanisms to translational imaging applications.Frontiers in bioengineering and biotechnology · 2026Review
- Single-Frequency Birdcage Coils for Deep Tissue Perfluorocarbon Magnetic Resonance Imaging in Mice.NMR in biomedicine · 2025Article
- Essential magnetosome proteins MamI and MamL from magnetotactic bacteria interact in mammalian cells.Scientific reports · 2024Article
- Iron-Related Genes and Proteins in Mesenchymal Stem Cell Detection and Therapy.Stem cell reviews and reports · 2023Review
- Designing Protein-Based Probes for Sensing Biological Analytes with Magnetic Resonance Imaging.Analysis & sensing · 2022Article
- Magnetic Iron Oxide Nanoparticles for Biomedical Applications.Current opinion in biomedical engineering · 2021Article
- Immunological Responses to Transgene-Modified Neural Stem Cells After Transplantation.Frontiers in immunology · 2021Article
- In Vivo Biosynthesis of Inorganic Nanomaterials Using Eukaryotes-A Review.Molecules (Basel, Switzerland) · 2020Review
- Non-invasive Reporter Gene Imaging of Cell Therapies, including T Cells and Stem Cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2020Review
- How Non-invasiveFrontiers in physiology · 2020Review
- Intrinsically Magnetic Cells: A Review on Their Natural Occurrence and Synthetic Generation.Frontiers in bioengineering and biotechnology · 2020Review
- Magnetic Iron Oxide Nanoparticles for Disease Detection and Therapy.Materials today (Kidlington, England) · 2019Article
- Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities.Cancer medicine · 2019Review
- MagA expression attenuates iron export activity in undifferentiated multipotent P19 cells.PloS one · 2019Article
- The Potential of Intrinsically Magnetic Mesenchymal Stem Cells for Tissue Engineering.International journal of molecular sciences · 2018Review
- Distribution of magnetic remanence carriers in the human brain.Scientific reports · 2018Article
- Probing the brain with molecular fMRI.Current opinion in neurobiology · 2018Review
- Gas vesicles as collapsible MRI contrast agents.Nature materials · 2018Article
- The potential roles of bacteria to improve radiation treatment outcome.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018Review
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Magnetic resonance imaging (MRI) is routinely used to obtain anatomical images that have greatly advanced biomedical research and clinical health care today, but the full potential of MRI in providing functional, physiological, and molecular information is only beginning to emerge. In this work, we sought to provide a gene expression marker for MRI based on bacterial magnetosomes, tiny magnets produced by naturally occurring magnetotactic bacteria. Specifically, magA, a gene in magnetotactic bacteria known to be involved with iron transport, is expressed in a commonly used human cell line, 293FT, resulting in the production of magnetic, iron-oxide nanoparticles by these cells and leading to increased transverse relaxivity. MRI shows that these particles can be formed in vivo utilizing endogenous iron and can be used to visualize cells positive for magA. These results demonstrate that magA alone is sufficient to produce magnetic nanoparticles and that it is an appropriate candidate for an MRI reporter gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.