ArticleDevelopmental neurobiology2008
Cadherin-6 function in zebrafish retinal development.
Article in Developmental neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Derivation of functional retinal endothelial cells from human pluripotent stem cells for therapeutics and modelling.Nature biomedical engineering · 2026Article
- Persistent Cytotoxic Immune Signaling in Anti-VEGF-Treated Neovascular Age-Related Macular Degeneration.medRxiv : the preprint server for health sciences · 2026Article
- Analysis of Axonal Regrowth and Dendritic Remodeling After Optic Nerve Crush in Adult Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2023Article
- An Antagonistic Axon-Dendrite Interplay Enables Efficient Neuronal Repair in the Adult Zebrafish Central Nervous System.Molecular neurobiology · 2019Article
- Article
- The hyaloid vasculature facilitates basement membrane breakdown during choroid fissure closure in the zebrafish eye.Developmental biology · 2016Article
- Protocadherin-17 function in Zebrafish retinal development.Developmental neurobiology · 2013Article
- Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells.Molecular biology of the cell · 2012Article
- Methylated promoters of genes encoding protocadherins as a new cancer biomarker family.Molecular biology reports · 2012Article
- Cell adhesion molecule cadherin-6 function in zebrafish cranial and lateral line ganglia development.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Identification of a locus for autosomal dominant high myopia on chromosome 5p13.3-p15.1 in a Chinese family.Molecular vision · 2010Article
- Differential gene expression in the developing human macula: microarray analysis using rare tissue samples.Journal of ocular biology, diseases, and informatics · 2009Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Cadherin cell-adhesion molecules play crucial roles in vertebrate development including the development of the visual system. Most studies have focused on examining functions of classical type I cadherins (e.g., cadherin-2) in visual system development. There is little information on the function of classical type II cadherins (e.g., cadherin-6) in the development of the vertebrate visual system. To gain insight into cadherin-6 role in the formation of the retina, we analyzed differentiation of retinal ganglion cells (RGCs), amacrine cells, and photoreceptors in zebrafish embryos injected with cadherin-6 specific antisense morpholino oligonucleotides. Differentiation of the retinal neurons in cadherin-6 knockdown embryos (cdh6 morphants) was analyzed using multiple markers. We found that expression of transcription factors important for retinal development was greatly reduced, and expression of Notch-Delta genes and proneural gene ath5 was altered in the cdh6 morphant retina. The retinal lamination was present in the morphants, although the morphant eyes were significantly smaller than control embryos due mainly to decreased cell proliferation. Differentiation of the RGCs, amacrine cells, and photoreceptors was severely disrupted in the cdh6 morphants due to a significant delay in neural differentiation. Our results suggest that cadherin-6 plays an important role in the normal formation of the zebrafish retina. (c) 2008 Wiley Periodicals, Inc. Develop Neurobiol, 2008.
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