ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2009
Methionine sulfoxide reductase: a novel schizophrenia candidate gene.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Analysis of biased allelic enhancer activity of schizophrenia-linked common variants.Communications biology · 2025Article
- βIV spectrin abundancy, cellular distribution and sensitivity to AKT/GSK3 regulation in schizophrenia.Molecular psychiatry · 2025Article
- Unveiling the Metabolic Trajectory of Pig Feces Across Different Ages and Senescence.Metabolites · 2024Article
- Methionine sulfoxide and the methionine sulfoxide reductase system as modulators of signal transduction pathways: a review.Amino acids · 2021Review
- Convergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Oxidative Stress-Related Mechanisms in Schizophrenia Pathogenesis and New Treatment Perspectives.Oxidative medicine and cellular longevity · 2021Review
- Novel Insight Into the Etiology of Autism Spectrum Disorder Gained by Integrating Expression Data With Genome-wide Association Statistics.Biological psychiatry · 2019Article
- High Incidence of Copy Number Variants in Adults with Intellectual Disability and Co-morbid Psychiatric Disorders.Behavior genetics · 2018Article
- Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.Frontiers in psychiatry · 2018Article
- HDAC1 links early life stress to schizophrenia-like phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The enzymatic activities of brain catechol-O-methyltransferase (COMT) and methionine sulphoxide reductase are correlated in a COMT Val/Met allele-dependent fashion.Neuropathology and applied neurobiology · 2015Article
- Multivariate genetic determinants of EEG oscillations in schizophrenia and psychotic bipolar disorder from the BSNIP study.Translational psychiatry · 2015Article
- Genetic Sources of Subcomponents of Event-Related Potential in the Dimension of Psychosis Analyzed From the B-SNIP Study.The American journal of psychiatry · 2015Article
- A protective role of methionine-R-sulfoxide reductase against cadmium in Schizosaccharomyces pombe.Journal of microbiology (Seoul, Korea) · 2014Article
- Genetic, psychosocial and clinical factors associated with hippocampal volume in the general population.Translational psychiatry · 2014Article
- Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A proximity-based method to identify genomic regions correlated with a continuously varying environmental variable.Evolutionary bioinformatics online · 2013Article
- Article
- Total RNA sequencing reveals nascent transcription and widespread co-transcriptional splicing in the human brain.Nature structural & molecular biology · 2011Article
- Genetic association studies of antioxidant pathway genes and schizophrenia.Antioxidants & redox signaling · 2011Review
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
Abstract
Methionine sulfoxide reductase (MSRA) is an antioxidant enzyme implicated in protection against oxidative stress and protein maintenance. We have previously reported the association of marker D8S542, located within the MSRA gene, with schizophrenia in the Central Valley of Costa Rica (CVCR). By performing fine mapping analysis, we have now identified a potential three-marker at risk haplotype within MSRA in the same CVCR sample, with a global P-value slightly above nominal significance (P = 0.0526). By sequencing the MSRA gene in individuals carrying this haplotype, we identified a novel 4-base pair deletion 1,792 bases upstream of the MSRA transcription start site. This deletion was significantly under-transmitted to schizophrenia patients in the CVCR sample (P = 0.0292) using FBAT, and this was replicated in a large independent sample of 321 schizophrenia families from the Hispanic population (P = 0.0367). These findings suggest a protective effect of the deletion against schizophrenia. Further, MSRA mRNA levels were significantly lower in lymphoblastoid cell lines of individuals homozygous for the deletion compared to carriers of the normal allele (P = 0.0135), although significance was only evident when genotypes were collapsed. This suggests that the deleted sequence may play a role in regulating MSRA expression. In conclusion, this work points towards MSRA as a novel schizophrenia candidate gene. Further studies into the mechanisms by which MSRA is involved in schizophrenia pathophysiology may shed light into the biological underpinnings of this disorder.
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