ArticleNeurocritical care2008
Recurrent takotsubo cardiomyopathy triggered by convulsive status epilepticus.
Article in Neurocritical care, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Left Ventricular Ballooning Patterns in Recurrent Takotsubo Cardiomyopathy: A Systematic Review and Meta-analysis of Reported Cases.Texas Heart Institute journal · 2021Pooled it
- Cardiac manifestations of prolonged seizure: A case report on reverse takotsubo syndrome and neurogenic stunned myocardium.Radiology case reports · 2025Article
- Takotsubo Cardiomyopathy in Epilepsy: A Systematic insight into the Existing Literature from 2000-2023.Pakistan journal of medical sciences · 2024Review
- Article
- Recurrent biventricular takotsubo cardiomyopathy with fatal outcome.BMJ case reports · 2022Article
- Article
- Recurrent Stress-Induced Cardiomyopathy With Cardiogenic Shock Requiring Impella Left Ventricular Assist Device.Cureus · 2021Article
- Article
- Takotsubo cardiomyopathy triggered by status epilepticus: case report and literature review.BMJ case reports · 2019Review
- Recurrence of Postoperative Stress-Induced Cardiomyopathy Resulting from Status Epilepticus.Case reports in critical care · 2017Article
- Regenerative Medicine: Potential Mechanisms of Cardiac Recovery in Takotsubo Cardiomyopathy.Current treatment options in cardiovascular medicine · 2016Article
- Recurrent takotsubo cardiomyopathy in the setting of transient neurological symptoms: a case report.Journal of medical case reports · 2011Article
- Autonomic and cellular mechanisms mediating detrimental cardiac effects of status epilepticus.Epilepsy research · 2010Article
- Elevation of Cardiac Troponins in Prolonged Status Epilepticus: A Retrospective Chart Analysis.SOJ neurologyArticle
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTakotsubo cardiomyopathy can complicate several conditions including neurological emergencies. A few recurrent cases associated with seizures have been reported, but none of the patients had status epilepticus. The pathophysiology of takotsubo syndrome, although debated, may involve stunning of the myocardium by a catecholamine storm triggered by stress. Patients with epilepsy may be at increased risk for takotsubo syndrome, which may occur repeatedly.
methodsWe report on a postmenopausal woman with symptomatic epilepsy who experienced recurrent takotsubo cardiomyopathy triggered by convulsive status epilepticus. Brief seizures were not associated with takotsubo syndrome. The relevant literature was reviewed.
resultsOver a 1-year period, she experienced two episodes of convulsive status epilepticus with complete neurological recovery after treatment. Echocardiography showed latero-septo-apical hypokinesia and apical ballooning. The cardiac abnormalities resolved fully and she recovered her baseline level of self-sufficiency. During the same period, she experienced several brief seizures, with no cardiac manifestations.
conclusionThe occurrence of takotsubo cardiomyopathy in association with convulsive status epilepticus, but not with brief seizures, supports neurogenically mediated myocardial stunning related to direct toxicity of endogenous catecholamines. Neuro-intensivists must be aware of this potentially fatal but fully reversible cardiac complication, which may be among the causes of death in patients with status epilepticus.
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