ArticleJournal of computational neuroscience2008
Simulation system of spinal cord motor nuclei and associated nerves and muscles, in a Web-based architecture.
Article in Journal of computational neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Automating population construction and parallel simulation of biophysical models for neuromuscular cells: An inverse approach.PLoS computational biology · 2026Article
- The variability of reflex amplitude estimates in motor unit pools depends on the phenotype distribution and discharge statistics.bioRxiv : the preprint server for biology · 2026Article
- Personalized mapping of inhibitory spinal cord circuits in humans via noninvasive neural decoding and in silico modeling.Science advances · 2025Article
- Peripheral neural interfaces for reading high-frequency brain signals.Nature biomedical engineering · 2025Review
- Neural control meets biomechanics in the motor assessment of neurological disorders: a narrative review.Frontiers in neural circuits · 2025Review
- Article
- Neural-driven activation of 3D muscle within a finite element framework: exploring applications in healthy and neurodegenerative simulations.Computer methods in biomechanics and biomedical engineering · 2024Article
- Article
- Postinhibitory excitation in motoneurons can be facilitated by hyperpolarization-activated inward currents: A simulation study.PLoS computational biology · 2024Article
- Spectral characterization of human leg EMG signals from an open access dataset for the development of computational models.PloS one · 2024Article
- Two motor neuron synergies, invariant across ankle joint angles, activate the triceps surae during plantarflexion.The Journal of physiology · 2023Article
- Linking cortex and contraction-Integrating models along the corticomuscular pathway.Frontiers in physiology · 2023Article
- Article
- Estimation of the firing behaviour of a complete motoneuron pool by combining electromyography signal decomposition and realistic motoneuron modelling.PLoS computational biology · 2022Article
- Effects of voluntary contraction on the soleus H-reflex of different amplitudes in healthy young adults and in the elderly.Frontiers in human neuroscience · 2022Article
- Integration of neural architecture within a finite element framework for improved neuromusculoskeletal modeling.Scientific reports · 2021Article
- Experimental and Computational Study on Motor Control and Recovery After Stroke: Toward a Constructive Loop Between Experimental and Virtual Embodied Neuroscience.Frontiers in systems neuroscience · 2020Article
- Influence of age on motor control accuracy during static ramp contractions.Experimental brain research · 2019Article
- Amplitude cancellation influences the association between frequency components in the neural drive to muscle and the rectified EMG signal.PLoS computational biology · 2019Article
- Curated Model Development Using NEUROiD: A Web-Based NEUROmotor Integration and Design Platform.Frontiers in neuroinformatics · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A Web-based simulation system of the spinal cord circuitry responsible for muscle control is described. The simulator employs two-compartment motoneuron models for S, FR and FF types, with synaptic inputs acting through conductance variations. Four motoneuron pools with their associated interneurons are represented in the simulator, with the possibility of inclusion of more than 2,000 neurons and 2,000,000 synapses. Each motoneuron action potential is followed, after a conduction delay, by a motor unit potential and a motor unit twitch. The sums of all motor unit potentials and twitches result in the electromyogram (EMG), and the muscle force, respectively. Inputs to the motoneuron pool come from populations of interneurons (Ia reciprocal inhibitory interneurons, Ib interneurons, and Renshaw cells) and from stochastic point processes associated with descending tracts. To simulate human electrophysiological experiments, the simulator incorporates external nerve stimulation with orthodromic and antidromic propagation. This provides the mechanisms for reflex generation and activation of spinal neuronal circuits that modulate the activity of another motoneuron pool (e.g., by reciprocal inhibition). The generation of the H-reflex by the Ia-motoneuron pool system and its modulation by spinal cord interneurons is included in the simulation system. Studies with the simulator may include the statistics of individual motoneuron or interneuron spike trains or the collective effect of a motor nucleus on the dynamics of muscle force control. Properties associated with motor-unit recruitment, motor-unit synchronization, recurrent inhibition and reciprocal inhibition may be investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.