ArticleArchives of virology2008
Genome comparison of virulent and avirulent strains of the Pichinde arenavirus.
Article in Archives of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack.Cell reports. Medicine · 2021Article
- RIG-I and MDA5 Protect Mice From Pichinde Virus Infection by Controlling Viral Replication and Regulating Immune Responses to the Infection.Frontiers in immunology · 2021Article
- Ancient Evolution of Mammarenaviruses: Adaptation via Changes in the L Protein and No Evidence for Host-Virus Codivergence.Genome biology and evolution · 2018Article
- In vitro and in vivo characterizations of pichinde viral nucleoprotein exoribonuclease functions.Journal of virology · 2015Article
- The Z proteins of pathogenic but not nonpathogenic arenaviruses inhibit RIG-I-like receptor-dependent interferon production.Journal of virology · 2015Article
- Watching every step of the way: junín virus attenuation markers in the vaccine lineage.Current genomics · 2013Article
- Identification of virulence determinants within the L genomic segment of the pichinde arenavirus.Journal of virology · 2013Article
- Characterization of virulence-associated determinants in the envelope glycoprotein of Pichinde virus.Virology · 2012Article
- Biological roles and functional mechanisms of arenavirus Z protein in viral replication.Journal of virology · 2012Article
- Arenavirus nucleoproteins prevent activation of nuclear factor kappa B.Journal of virology · 2012Article
- Article
- Molecular analysis of the virulence attenuation process in Junín virus vaccine genealogy.Virus genes · 2010Article
- Proteomic analysis of Pichindé virus infection identifies differential expression of prothymosin-alpha.Journal of biomedicine & biotechnology · 2010Article
- Comparative pathogenesis and systems biology for biodefense virus vaccine development.Journal of biomedicine & biotechnology · 2010Review
- Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus.Journal of virology · 2009Article
- Molecular determinants of Pichinde virus infection of guinea pigs--a small animal model system for arenaviral hemorrhagic fevers.Annals of the New York Academy of Sciences · 2009Article
- Development of infectious clones for virulent and avirulent pichinde viruses: a model virus to study arenavirus-induced hemorrhagic fevers.Journal of virology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
A virulent (P18) strain of the Pichinde arenavirus produces a disease in guinea pigs that somewhat mimics human Lassa fever, whereas an avirulent (P2) strain of this virus is attenuated in infected animals. It has been speculated that the composition of viral genomes may confer the degree of virulence in an infected host; the complete sequence of the viral genomes, however, is not known. Here, we provide for the first time genomic sequences of the S and L segments for both the P2 and P18 strains. Sequence comparisons identify three mutations in the GP1 subunit of the viral glycoprotein, one in the nucleoprotein NP, and five in the viral RNA polymerase L protein. These mutations, alone or in combination, may contribute to the acquired virulence of Pichinde virus infection in animals. The three amino acid changes in the variable region of the GP1 glycoprotein subunit may affect viral entry by altering its receptor-binding activity. While NP has previously been shown to modulate host immune responses to viral infection, we found that the R374 K change in this protein does not affect the NP function of suppressing interferon-beta expression. Four out of the five amino acid changes in the L protein occur in a small region of the protein that may contribute to viral virulence by enhancing its function in viral genomic RNA synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.