Trial reportPsychopharmacology2008
Acute tryptophan depletion in healthy males attenuates phasic cardiac slowing but does not affect electro-cortical response to negative feedback.
Trial report in Psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Acute tryptophan depletion attenuates conscious appraisal of social emotional signals in healthy female volunteers.Psychopharmacology · 2011Trial
- Different Electrophysiological Responses to Informative Value of Feedback Between Children and Adults.Frontiers in psychology · 2018Article
- Electrophysiological Response to the Informative Value of Feedback Revealed in a Segmented Wisconsin Card Sorting Test.Frontiers in psychology · 2018Article
- Acute tryptophan depletion attenuates brain-heart coupling following external feedback.Frontiers in human neuroscience · 2012Article
- Dissociation between medial frontal negativity and cardiac responses in the ultimatum game: Effects of offer size and fairness.Cognitive, affective & behavioral neuroscience · 2011Article
- Serotonin and dopamine play complementary roles in gambling to recover losses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- How human electrophysiology informs psychopharmacology: from bottom-up driven processing to top-down control.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Review
- The antimalarial drug quinine disrupts Tat2p-mediated tryptophan transport and causes tryptophan starvation.The Journal of biological chemistry · 2009Article
- Cardiac slowing and acute tryptophan depletion: a comment on the paper by van der Veen et al.Psychopharmacology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleRecent studies have shown that serotonin might be involved in performance monitoring, although the results have been inconclusive. Inconsistent results might be related to the type of pharmacological manipulation and the used behavioral and physiological measures.
objectivesThe present study aimed at further specifying the role of serotonin in performance monitoring. MATERIALS AND
methodsThe effect of serotonin on performance monitoring was studied by using acute tryptophan depletion (ATD), a well-known method to transiently lower central serotonin levels. Twenty healthy male volunteers performed a time-estimation task and their event-related brain potential (ERP), behavioral, and cardiac responses to feedback stimuli were measured. Furthermore, subjective mood and amino-acid levels were determined.
resultsAs expected, ATD did not affect mood and lowered tryptophan levels. ATD attenuated cardiac slowing to negative feedback but did not affect responses to positive feedback, ERPs, and performance measures.
conclusionsThe data point in the direction of a dissociation between cardiac and electro-cortical responses. Cardiac responses appear to be more sensitive to changes in serotonin metabolism and appear to reflect different aspects of the feedback stimulus. The phasic cardiac response appears to be an important measure that provides additional information about the impact of feedback stimuli and serotonergic functioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.