ArticleGenetics2008
Overdispersion of the molecular clock varies between yeast, Drosophila and mammals.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Epistasis plays a limited role in driving entrenchment during neutral protein evolution.Genome biology · 2026Article
- PyEvoMotion: a Python tool for population-based time-course analysis of genome evolution.Bioinformatics (Oxford, England) · 2026Article
- A variant-dependent molecular clock with anomalous diffusion models SARS-CoV-2 evolution in humans.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Epistatic contributions promote the unification of incompatible models of neutral molecular evolution.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Clonal evolution of glioblastoma under therapy.Nature genetics · 2016Article
- Rate of evolutionary change in cranial morphology of the marsupial genus Monodelphis is constrained by the availability of additive genetic variation.Journal of evolutionary biology · 2015Article
- Scombroid fishes provide novel insights into the trait/rate associations of molecular evolution.Journal of molecular evolution · 2014Article
- Universal pacemaker of genome evolution in animals and fungi and variation of evolutionary rates in diverse organisms.Genome biology and evolution · 2014Article
- Stability along with extreme variability in core genome evolution.Genome biology and evolution · 2013Article
- Why does a protein's evolutionary rate vary over time?Genome biology and evolution · 2013Article
- Universal pacemaker of genome evolution.PLoS computational biology · 2012Article
- Pervasive cryptic epistasis in molecular evolution.PLoS genetics · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Although protein evolution can be approximated as a "molecular evolutionary clock," it is well known that sequence change departs from a clock-like Poisson expectation. Through studying the deviations from a molecular clock, insight can be gained into the forces shaping evolution at the level of proteins. Generally, substitution patterns that show greater variance than the Poisson expectation are said to be "overdispersed." Overdispersion of sequence change may result from temporal variation in the rate at which amino acid substitutions occur on a phylogeny. By comparing the genomes of four species of yeast, five species of Drosophila, and five species of mammals, we show that the extent of overdispersion shows a strong negative correlation with the effective population size of these organisms. Yeast proteins show very little overdispersion, while mammalian proteins show substantial overdispersion. Additionally, X-linked genes, which have reduced effective population size, have gene products that show increased overdispersion in both Drosophila and mammals. Our research suggests that mutational robustness is more pervasive in organisms with large population sizes and that robustness acts to stabilize the molecular evolutionary clock of sequence change.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.