ArticleAmerican journal of physiology. Endocrinology and metabolism2008
Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice.
Article in American journal of physiology. Endocrinology and metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 71 citations in OpenAlex.
- A Road Map to Understanding Cardiovascular Disease in Diabetes: From the AHA Strategically Focused Research Network in Cardiometabolic Health and Type 2 Diabetes.Circulation research · 2026Review
- Variants of Visceral Adipocytokine Genes in Obesity and Coronary Atherosclerosis: A Review.Current medicinal chemistry · 2026Review
- Ductular reaction in non-alcoholic fatty liver disease: When Macbeth is perverted.World journal of hepatology · 2023Review
- Adipokines in Non-Alcoholic Fatty Liver Disease: Are We on the Road toward New Biomarkers and Therapeutic Targets?Biology · 2022Review
- The Effects of Resistin Gene Polymorphism on Pain Thresholds and Postoperative Sufentanil Consumption in Gastric Cancer Patients.Journal of pain research · 2022Article
- Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease.Cell & bioscience · 2020Review
- Association between serum and adipose tissue resistin with dysglycemia in South Asian women.Nutrition & diabetes · 2019Article
- Cytokines and Abnormal Glucose and Lipid Metabolism.Frontiers in endocrinology · 2019Review
- Genistein diet improves body weight, serum glucose and triglyceride levels in both male and female ob/ob mice.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Profiles of metabolic gene expression in the white adipose tissue, liver and hypothalamus in leptin knockout (LepJournal of biomedical research · 2017Article
- Development of gene polymorphisms in meditators of nonalcoholic fatty liver disease.Biomedical reports · 2017Article
- Normalization of adiponectin concentrations by leptin replacement in ob/ob mice is accompanied by reductions in systemic oxidative stress and inflammation.Scientific reports · 2017Article
- Adipokines in psoriasis: An important link between skin inflammation and metabolic alterations.Reviews in endocrine & metabolic disorders · 2016Review
- Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease.Oxidative medicine and cellular longevity · 2016Review
- GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cells.World journal of gastroenterology · 2014Article
- Review
- Lack of kinin B₁ receptor potentiates leptin action in the liver.Journal of molecular medicine (Berlin, Germany) · 2013Article
- Resistin expression correlates with steatohepatitis in morbidly obese patients.Surgical endoscopy · 2013Article
- Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver.Molecular and cellular endocrinology · 2013Review
- Nuciferine prevents hepatic steatosis and injury induced by a high-fat diet in hamsters.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Resistin has been linked to components of the metabolic syndrome, including obesity, insulin resistance, and hyperlipidemia. We hypothesized that resistin deficiency would reverse hyperlipidemia in genetic obesity. C57Bl/6J mice lacking resistin [resistin knockout (RKO)] had similar body weight and fat as wild-type mice when fed standard rodent chow or a high-fat diet. Nonetheless, hepatic steatosis, serum cholesterol, and very low-density lipoprotein (VLDL) secretion were decreased in diet-induced obese RKO mice. Resistin deficiency exacerbated obesity in ob/ob mice, but hepatic steatosis was drastically attenuated. Moreover, the levels of triglycerides, cholesterol, insulin, and glucose were reduced in ob/ob-RKO mice. The antisteatotic effect of resistin deficiency was related to reductions in the expression of genes involved in hepatic lipogenesis and VLDL export. Together, these results demonstrate a crucial role of resistin in promoting hepatic steatosis and hyperlipidemia in obese mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.