ArticleBMC medical genetics2008
Evaluation of the association between the common E469K polymorphism in the ICAM-1 gene and diabetic nephropathy among type 1 diabetic patients in GoKinD population.
Article in BMC medical genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Association between E469K polymorphism in the ICAM1 gene and the risk of diabetic nephropathy: a meta-analysis.Lipids in health and disease · 2018Pooled it
- Intracellular adhesion molecule-1 K469E gene polymorphism and risk of diabetic microvascular complications: a meta-analysis.PloS one · 2013Pooled it
- Association of ICAM-1 Gene Polymorphisms with Diabetic Retinopathy in T2DM Patients from Northern India: Case-control and meta-analysis.World journal of diabetes · 2025Article
- Polymorphisms in the intercellular adhesion molecule 1 gene and cancer risk: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Association of intercellular adhesion molecule 1 (ICAM1) with diabetes and diabetic nephropathy.Frontiers in endocrinology · 2012Article
- Article
- Insights to the genetics of diabetic nephropathy through a genome-wide association study of the GoKinD collection.Seminars in nephrology · 2010Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ICAM-1 gene is a strong positional and biological candidate for susceptibility to the development of T1D and DN. We have recently demonstrated that SNP rs5498(E469K) confers susceptibility to the development of T1D and might be associated with DN in Swedish Caucasians. The present study aimed to further evaluate the association between the ICAM-1 genetic polymorphisms and DN.
methodsTwo common non-synonymous SNPs, including rs5498(E469K) and rs1799969(R241G), in the ICAM-1 gene were genotyped in 662 (312 female/350 male) T1D patients with DN and 620 (369/251) without DN. All patients were selected from the GoKinD study.
resultsGenotype distributions of both SNPs were in Hardy-Weinberg equilibrium but SNP rs5498(E469K) had high heterozygous index. In this SNP, the heterozygosity and positivity for the allele G were found to be significantly associated with DN in female T1D patients (P = 0.010, OR = 0.633, CI 95% 0.447-0.895 and P = 0.026, OR = 0.692, CI 95% 0.500-0.958). Furthermore, the female patients without DN carrying three genotypes A/A, A/G and G/G had different cystatin levels (0.79 +/- 0.17, 0.81 +/- 0.14 and 0.75 +/- 0.12 mg/L, P = 0.021). No significant association of SNP rs1799969 (R241G) with DN was found.
conclusionThe present study provides further evidence that SNP rs5498(E469K) in the ICAM-1 gene presents a high heterozygous index and the allele G of this polymorphism may confers the decreased risk susceptibility to the development of DN in female T1D patients among the GoKinD population.
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