ArticleClinical and experimental immunology2008
Effect of tumour necrosis factor-alpha receptor 1 genetic deletion on carrageenan-induced acute inflammation: a comparison with etanercept.
Article in Clinical and experimental immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs.Veterinary sciences · 2021Article
- TRPV1 Blocker HCRG21 Suppresses TNF-α Production and Prevents the Development of Edema and Hypersensitivity in Carrageenan-Induced Acute Local Inflammation.Biomedicines · 2021Article
- Insightful Valorization of the Biological Activities of Pani Heloch Leaves through Experimental and Computer-Aided Mechanisms.Molecules (Basel, Switzerland) · 2020Article
- Article
- Antiedematogenic and Anti-Inflammatory Activity of the Monoterpene Isopulegol and Its β-Cyclodextrin (β-CD) Inclusion Complex in Animal Inflammation Models.Foods (Basel, Switzerland) · 2020Article
- Clindamycin inhibits nociceptive response by reducing tumor necrosis factor-α and CXCL-1 production and activating opioidergic mechanisms.Inflammopharmacology · 2020Article
- Antinociceptive and Anxiolytic and Sedative Effects of Methanol Extract ofFrontiers in pharmacology · 2018Article
- A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade.American journal of hematology · 2017Article
- Article
- Etanercept administration prevents the inflammatory response induced by carrageenan in the murine air pouch model.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- Systemic changes following carrageenan-induced paw inflammation in rats.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
- Pulmonary inflammation is regulated by the levels of the vesicular acetylcholine transporter.PloS one · 2015Article
- Antinociceptive activity of the ethanolic extract, fractions, and aggregatin D isolated from Sinningia aggregata tubers.PloS one · 2015Article
- Beneficial effects of Etanercept on experimental necrotizing enterocolitis.Pediatric surgery international · 2014Article
- Anti-inflammatory effect of quinoline alkaloid skimmianine isolated from Ruta graveolens L.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Article
- Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema.Journal of inflammation (London, England) · 2012Article
- TRPA1 contributes to the acute inflammatory response and mediates carrageenan-induced paw edema in the mouse.Scientific reports · 2012Article
- Isolation, characterization and quantification of tricin and flavonolignans in the medicinal rice Njavara (Oryza sativa L.), as compared to staple varieties.Plant foods for human nutrition (Dordrecht, Netherlands) · 2011Article
- TNF/TNFR1 signaling mediates doxorubicin-induced diaphragm weakness.American journal of physiology. Lung cellular and molecular physiology · 2011Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, we used tumour necrosis factor-alpha receptor 1 knock-out mice (TNF-alphaR1KO) to evaluate an in vivo role of TNF-alphaR1 on the pathogenesis of inflammatory diseases. We used a murine model of carrageenan-induced acute inflammation (pleurisy), a preclinical model of airway inflammation. The data proved that TNF-alphaR1KO were resistant to carrageenan-induced acute inflammation compared with TNF-alpha wild-type mice. TNF-alphaR1KO showed a significant reduction in accumulation of pleural exudate and in the number of inflammatory cells, in lung infiltration of polymorphonuclear leucocytes and lipid peroxidation and showed a decreased production of nitrite/nitrate in pleural exudates. Furthermore, the intensity and degree of the adhesion molecule intercellular adhesion molecule-1 and P-selectin, Fas ligand (FasL), inducible nitric oxide sythase and nitrotyrosine determined by immunohistochemical analysis were reduced markedly in lung tissues from TNF-alphaR1KO at 4 h and 24 h after carrageenan injection. Moreover, TNF-alpha and interleukin-1beta concentrations were reduced in inflamed areas and in pleural exudates from TNF-alphaR1KO. To support the results generated using pleural inflammation, carrageenan-induced paw oedema models were also performed. In order to elucidate whether the observed anti-inflammatory effects were related to the inhibition of TNF-alpha, we also investigated the effect of etanercept, a TNF-alpha soluble receptor construct, on carrageenan-induced pleurisy. The treatment with etanercept (5 mg/kg subcutaneously 2 h before the carrageenan injection) reduces markedly both laboratory and histological signs of carrageenan-induced pleurisy. Our results showed that administration of etanercept resulted in the same outcome as that of deletion of the TNF-alphaR1 receptor, adding a new insight to TNF-alpha as an excellent target by therapeutic applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.