ArticleThe Journal of infectious diseases2008
Transmission and detection of prions in feces.
Article in The Journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
81 citing papers in PubMed, 144 citations in OpenAlex.
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- Emerging risks at the vampire bat-prion interface: implications for wildlife, livestock, and public health.Journal of mammalogy · 2026Article
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- Vertical transmission of chronic wasting disease in free-ranging white-tailed deer populations.Scientific reports · 2025Article
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- PMCA screening of retropharyngeal lymph nodes in white-tailed deer and comparisons with ELISA and IHC.Scientific reports · 2023Article
- Propagation of PrPCommunications biology · 2023Article
- Coprophagy in moose: A first observation.Ecology and evolution · 2023Article
- Longitudinal detection of prion shedding in nasal secretions of CWD-infected white-tailed deer.The Journal of general virology · 2023Article
- Characteristic distribution and molecular properties of normal cellular prion protein in human endocrine and exocrine tissues.Scientific reports · 2022Article
- Review
- Modeling the Impact of Climate Change on Cervid Chronic Wasting Disease in Semi-Arid South Texas.Frontiers in epidemiology · 2022Article
- Detection of Chronic Wasting Disease Prions in Fetal Tissues of Free-Ranging White-Tailed Deer.Viruses · 2021Article
- Chronic wasting disease in Europe: new strains on the horizon.Acta veterinaria Scandinavica · 2021Review
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- Short-Term Cohousing of Sick with Healthy or Treated Mice Alleviates the Inflammatory Response and Liver Damage.Inflammation · 2021Article
- Post-Translational Protein Deimination Signatures in Plasma and Plasma EVs of Reindeer (Biology · 2021Article
- Cervid Prion Protein Polymorphisms: Role in Chronic Wasting Disease Pathogenesis.International journal of molecular sciences · 2021Review
- Large-scale prion protein genotyping in Canadian caribou populations and potential impact on chronic wasting disease susceptibility.Molecular ecology · 2020Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
In chronic wasting disease (CWD) in cervids and in scrapie in sheep, prions appear to be transmitted horizontally. Oral exposure to prion-tainted blood, urine, saliva, and feces has been suggested as the mode of transmission of CWD and scrapie among herbivores susceptible to these prion diseases. To explore the transmission of prions through feces, uninoculated Syrian hamsters (SHas) were cohabitated with or exposed to the bedding of SHas orally infected with Sc237 prions. Incubation times of 140 days and a rate of prion infection of 80%-100% among exposed animals suggested transmission by feces, probably via coprophagy. We measured the disease-causing isoform of the prion protein (PrP(Sc)) in feces by use of the conformation-dependent immunoassay, and we titrated the irradiated feces intracerebrally in transgenic mice that overexpressed SHa prion protein (SHaPrP). Fecal samples collected from infected SHas in the first 7 days after oral challenge harbored 60 ng/g PrP(Sc) and prion titers of approximately 10(6.6) ID(50)/g. Excretion of infectious prions continued at lower levels throughout the asymptomatic phase of the incubation period, most likely by the shedding of prions from infected Peyer patches. Our findings suggest that horizontal transmission of disease among herbivores may occur through the consumption of feces or foodstuff tainted with prions from feces of CWD-infected cervids and scrapie-infected sheep.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.