Trial reportEuropean archives of psychiatry and clinical neuroscience2008
Abnormal amygdala activation profile in pedophilia.
Trial report in European archives of psychiatry and clinical neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Using physiological biomarkers in forensic psychiatry: a scoping review.Frontiers in psychiatry · 2025Pooled it
- Idiopathic and acquired pedophilia as two distinct disorders: an insight from neuroimaging.Brain imaging and behavior · 2021Pooled it
- Neurocognitive Insights into Child Sexual Abuse Perpetrators: Understanding Cognitive and Emotional Profiles: A Case-Control Study.Iranian journal of medical sciences · 2025Article
- Modulation of the attentional response to baby schema by testosterone in pedohebephilic men and its relation to the nurturing system.Scientific reports · 2024Article
- Altered Neural and Behavioral Response to Sexually Implicit Stimuli During a Pictorial-Modified Stroop Task in Pedophilic Disorder.Biological psychiatry global open science · 2023Article
- Acquired Pedophilia: international Delphi-method-based consensus guidelines.Translational psychiatry · 2023Review
- Driving Behaviors in Iran: Comparison of Impulsivity, Attentional Bias, and Decision-Making Styles in Safe and High-Risk Drivers.Iranian journal of psychiatry · 2020Article
- Neuroanatomical Differences Among Sexual Offenders: A Targeted Review with Limitations and Implications for Future Directions.Violence and gender · 2020Review
- Brain responses to pictures of children in men with pedophilic disorder: a functional magnetic resonance imaging study.European archives of psychiatry and clinical neuroscience · 2019Article
- Are There Any Biomarkers for Pedophilia and Sexual Child Abuse? A Review.Frontiers in psychiatry · 2019Review
- Decoding Pedophilia: Increased Anterior Insula Response to Infant Animal Pictures.Frontiers in human neuroscience · 2017Article
- Neuroimaging and sexual behavior: identification of regional and functional differences.Current psychiatry reports · 2015Review
- Connectivity and functional profiling of abnormal brain structures in pedophilia.Human brain mapping · 2015Article
- The Neurobiology and Psychology of Pedophilia: Recent Advances and Challenges.Frontiers in human neuroscience · 2015Review
- The ins and outs of sexual imaging.AJNR. American journal of neuroradiology · 2014Article
- Changed processing of visual sexual stimuli under GnRH-therapy--a single case study in pedophilia using eye tracking and fMRI.BMC psychiatry · 2014Article
- Neuroimaging in pedophilia.Current psychiatry reports · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite considerable public interest research in neurobiological correlates of pedophilia is scarce. Since amygdala activation is central for emotional valuation, arousal, and salience, we investigated the activation profile of this structure in 10 male subjects with pedophilia (exclusively attracted to boys), all convicted sex-offenders and sentenced to forensic psychiatric treatment along with ten male heterosexual matched controls. We used a sexually non-explicit functional Magnetic Resonance Imaging (fMRI) paradigm with images of men, women, boys or girls randomly embedded in neutral target/non-target geometrical symbols. We applied statistical parametric mapping (SPM2) and SPSS 14 for image processing and analysis. While controls activated significantly less to pictures of children compared to adults, the activation profile was reversed in subjects with pedophilia, who exhibited significantly more activation to children than adults. The highest activation was observed for boys in the patient group, and for women in control participants. Our data show enhanced activation to children's pictures even in an incidental context and suggest the provocative hypothesis that a normally present mechanism for reduced emotional arousal for children relative to adults is reversed in pedophilia, suggesting a neural substrate associated with deviant sexual preference in this condition. More extensive research in this field would be of benefit for both the victims and the offenders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.