ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2008
Association between fatigue and other cancer-related symptoms in patients with advanced cancer.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Physical activity in patients with advanced-stage cancer: a systematic review of the literature.Clinical journal of oncology nursing · 2012Pooled it
- Physiotherapy programme reduces fatigue in patients with advanced cancer receiving palliative care: randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Trial
- Is education an effective management strategy for reducing cancer-related fatigue?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2011Trial
- Chronic Fatigue in Cancer Survivorship: Psychiatry Versus Oncology or Psychiatry with Oncology?Current oncology reports · 2025Review
- Relationship between physical function and quality of life based on treatment timing in patients with advanced lung cancer.Journal of physical therapy science · 2025Article
- Comprehensive assessment of pain characteristics, quality of life, and pain management in cancer patients: a multi-center cross-sectional study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Addressing cancer-related fatigue through sleep: A secondary analysis of a randomized trial comparing acupuncture and cognitive behavioral therapy for insomnia.Integrative medicine research · 2023Article
- Evaluating the Feasibility of a Digital Therapeutic Program for Patients With Cancer During Active Treatment: Pre-Post Interventional Study.JMIR formative research · 2022Article
- Feasibility and Health Benefits of an Individualized Physical Activity Intervention in Women With Metastatic Breast Cancer: Intervention Study.JMIR mHealth and uHealth · 2020Article
- Quality of life of Moroccan patients on the palliative phase of advanced cancer.BMC research notes · 2019Article
- Association between Daytime Activity, Fatigue, Sleep, Anxiety, Depression, and Symptom Burden in Advanced Cancer Patients: A Preliminary Report.Journal of palliative medicine · 2016Article
- Observational
- Usefulness of the PERFORM questionnaire to measure fatigue in cancer patients with anemia: a prospective, observational study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Observational
- Predictive factors for overall quality of life in patients with advanced cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Article
- Factors associated with the severity and improvement of fatigue in patients with advanced cancer presenting to an outpatient palliative care clinic.BMC palliative care · 2012Article
- An examination of distress, sleep, and fatigue in metastatic breast cancer patients.Psycho-oncology · 2012Article
- Functional evaluation indicates physical losses after hematopoietic stem cell transplantation.Revista brasileira de hematologia e hemoterapia · 2012Article
- Cancer-related fatigue: the impact of skeletal muscle mass and strength in patients with advanced cancer.Journal of cachexia, sarcopenia and muscle · 2010Article
- The moderating role of personal mastery on the relationship between caregiving status and multiple dimensions of fatigue.International journal of geriatric psychiatry · 2009Article
- Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
goals of workAlthough fatigue is the chronic symptom most commonly experienced by patients with advanced cancer, little research has been done on the associations and correlates of fatigue in this population. The aim of this study was, therefore, to determine whether fatigue scores, as measured by the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), are associated with age, gender, type of cancer diagnosed, pain, and other cancer-related symptoms measured using the Edmonton Symptom Assessment Scale (ESAS). MATERIALS AND
methodsWe retrospectively reviewed the FACIT-F (when a higher score denotes lower fatigue) and ESAS (when a lower fatigue score denotes lower fatigue intensity) scores of 268 patients with advanced cancer who had been previously enrolled in clinical trials of therapies for fatigue. To determine associations between variables, we performed univariate and multivariate analyses on the data.
resultsWe found no univariate association between fatigue score and gender, ethnicity (p = 0.31), or type of cancer diagnosed. Performance status was associated with fatigue (p < 0.0001). On multivariate analysis, we found, however, significant association between fatigue and pain (r = -0.20, p = 0.0012), nausea (r = -0.13, p = 0.04), anxiety (r = -0.27, p < 0.0001), fatigue and depression (r = -0.19, p = 0.0019), drowsiness (r = -0.24, p = 0.0002), dyspnea (r = -0.17, p = 0.007), anorexia (r = -0.29, p < 0.0001), insomnia (r = -0.25, p < 0.0001), and feelings of well-being (r = -0.37, p < 0.0001). Using backward stepwise logistic regression analysis, independent correlative factors associated with fatigue include well-being (p = .0003), drowsiness (0.006), anorexia (0.01), and anxiety (0.03). However, this model only explained 21% of the variation in the intensity of fatigue.
conclusionsAlthough we found that fatigue is significantly associated with the severity of psychological symptoms (anxiety and depression) and physical symptoms (pain, dyspnea, insomnia, anorexia, and drowsiness), additional research is required to confirm that these are indeed the main associations of fatigue and, by doing so, enable physicians to better characterize fatigue in patients receiving palliative care.
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