ArticleDevelopment genes and evolution2008
Context-dependent regulation of Hox protein functions by CK2 phosphorylation sites.
Article in Development genes and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Kinase Regulation of HOX Transcription Factors.Cancers · 2019Review
- Mechanisms of Specificity for Hox Factor Activity.Journal of developmental biology · 2016Article
- Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins.The Journal of biological chemistry · 2015Review
- Evolution of transcription factor function as a mechanism for changing metazoan developmental gene regulatory networks.EvoDevo · 2015Review
- Rethinking gene regulatory networks in light of alternative splicing, intrinsically disordered protein domains, and post-translational modifications.Frontiers in cell and developmental biology · 2015Article
- Directed neural differentiation of mouse embryonic stem cells is a sensitive system for the identification of novel Hox gene effectors.PloS one · 2011Article
- The role of casein kinase II in flowering time regulation has diversified during evolution.Plant physiology · 2010Article
- Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and PP2A during Drosophila neurogenesis.Genesis (New York, N.Y. : 2000) · 2009Article
- Internal regulatory interactions determine DNA binding specificity by a Hox transcription factor.Journal of molecular biology · 2009Article
- Drosophila protein kinase CK2 is rendered temperature-sensitive by mutations of highly conserved residues flanking the activation segment.Molecular and cellular biochemistry · 2009Article
- Hox specificity unique roles for cofactors and collaborators.Current topics in developmental biology · 2009Review
- Silencing of an abdominal Hox gene during early development is correlated with limb development in a crustacean trunk.Evolution & developmentArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Variations in Hox protein sequences and functions have been proposed to contribute to evolutionary changes in appendage shape and number in crustaceans and insects. One model is that insect Hox proteins of the Ultrabithorax (UBX) ortholog class evolved increased abilities to repress Distal-less (Dll) transcription and appendage development in part through the loss of serine and threonine residues in casein kinase 2 (CK2) phosphorylation sites. To explore this possibility, we constructed and tested the appendage repression function of chimeric proteins with insertions of different CK2 consensus sites or phosphomimetics of CK2 sites in C-terminal regions of Drosophila melanogaster UBX. Our results indicate that CK2 sites C-terminal to the homeodomain can inhibit the appendage repression functions of UBX proteins, but only in the context of specific amino acid sequences. Our results, combined with previous findings on evolutionary changes in Hox protein, suggest how intra-protein regulatory changes can diversify Hox protein function, and thus animal morphology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.