ArticlePlant cell reports2008
Dwarf plants of diploid Medicago sativa carry a mutation in the gibberellin 3-beta-hydroxylase gene.
Article in Plant cell reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- The ga3ox1b mutation reveals the crosstalk between gibberellin and other phytohormones in controlling the growth and development of female flowers in Cucurbita pepo.Journal of experimental botany · 2026Article
- Genotyping ofPlants (Basel, Switzerland) · 2025Article
- Transcription factor MdWRKY50 correlates with spur-type formation in apple by modulating endogenous gibberellin biosynthesis.BMC plant biology · 2025Article
- Pan-genomic analysis highlights genes associated with agronomic traits and enhances genomics-assisted breeding in alfalfa.Nature genetics · 2025Article
- The mutation of ent-kaurenoic acid oxidase, a key enzyme involved in gibberellin biosynthesis, confers a dwarf phenotype to cucumber.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
- Transcriptome and metabolome analyses reveal that GA3ox regulates the dwarf trait in mango (Mangifera indica L.).BMC plant biology · 2024Article
- Gibberellins Inhibit Flavonoid Biosynthesis and Promote Nitrogen Metabolism inInternational journal of molecular sciences · 2021Article
- The GA 20-Oxidase Encoding GeneFrontiers in plant science · 2021Article
- A mutation in the intron splice acceptor site of a GA3ox gene confers dwarf architecture in watermelon (Citrullus lanatus L.).Scientific reports · 2020Article
- Cloning and Functional Analysis of Dwarf GeneInternational journal of molecular sciences · 2020Article
- SRAP polymorphisms associated with superior freezing tolerance in alfalfa (Medicago sativa spp. sativa).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2010Article
- Genome-wide analysis reveals rapid and dynamic changes in miRNA and siRNA sequence and expression during ovule and fiber development in allotetraploid cotton (Gossypium hirsutum L.).Genome biology · 2009Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper we describe the identification of a gene, MsDWF1 coding for a putative gibberellin 3-beta-hydroxylase (GA3ox), whose natural mutation is conditioning a dwarf growth phenotype in Medicago sativa. The dwarf phenotype could not be complemented with grafting, which indicates that the bioactive gibberellin compound necessary for shoot elongation is immobile. On the contrary, exogenously added gibberellic acid restored normal growth. The genetic position of the Msdwf1 gene was mapped to linkage group 2 (LG2) and the physical location was delimited by map-based cloning using Medicago truncatula genomic resources. Based on the similar appearance and behavior of the dwarf Medicago sativa plants to the pea stem length mutant (le) as well as the synthenic map position of the two genes it was postulated that MsDWF1 and pea Le are orthologs. The comparison of wild type and mutant allele sequences of MsGA3ox revealed an amino acid change in a conserved position in the mutant allele, which most probably impaired the function of the enzyme. Our results indicate that the dwarf phenotype was the consequence of this mutation.
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