Evidence map›Paper›PMID 18504574›Full record

ArticleImmunogenetics2008

MHC class I characterization of Indonesian cynomolgus macaques.

Chad J Pendley, Ericka A Becker, Julie A Karl, Alex J Blasky, Roger W Wiseman, Austin L Hughes, Shelby L O'Connor, David H O'Connor

Open access · bronzeAbstract read
In one paragraph

Article in Immunogenetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. TNX-1500, a crystallizable fragment-modified anti-CD154 antibody, prolongs nonhuman primate renal allograft survival.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
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  8. Review
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  16. Immunosuppression With CD40 Costimulatory Blockade Plus Rapamycin for Simultaneous Islet-Kidney Transplantation in Nonhuman Primates.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chad J PendleyWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53706, USA.
Ericka A Becker
Julie A Karl
Alex J Blasky
Roger W Wiseman
Austin L Hughes
Shelby L O'Connor
David H O'Connor
University of Wisconsin–Madison · USUniversity of South Carolina · US

Funding

ZOLEDRONATE PREVENTS BONE LOSS IN OVARIECTOMIZED RHESUS MONKEYSP51RR000167 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI WATKINS, DAVID I · 1985 to 2011
$106.7M
EXTRAMURAL RES FACIL CONST: REPRODUCTIVE, GROWTH &DVMT, MENOPAUSEC06RR020141 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2004 to 2004
$3.6M
Immunogenetics of Primates Used for Bioterror ResearchR24RR021745 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2005 to 2011
$3.3M
EXTRAMURAL REGIONAL FACILITIES CONSTRUCTIONC06RR015459 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2000 to 2000
$1.9M
POLYMORPHISM &EVOLUTION OF MHC GENESR01GM043940 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HUGHES, AUSTIN L. · 1990 to 2010
$1.5M
IMTEK MICROCAT II MICROCT SCANNER: CYSTITIS, GENETICS, AND PROSTATE RESEARCHS10RR021041 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI WEICHERT, JAMEY PAUL · 2005 to 2005
$386k
NCRR NIH HHS 1 R24 RR021745-01A1NCRR NIH HHS C06 RR015459NCRR NIH HHS C06 RR020141NCRR NIH HHS P51 RR000167NCRR NIH HHS R24 RR021745NCRR NIH HHS RR020141-01NCRR NIH HHS RR15459-01NCRR NIH HHS S10 RR021041NIAID NIH HHS N01 AI040088NIGMS NIH HHS GM43940NIGMS NIH HHS R01 GM043940
6 · The paper itself

Abstract

Cynomolgus macaques (Macaca fascicularis) are quickly becoming a useful model for infectious disease and transplantation research. Even though cynomolgus macaques from different geographic regions are used for these studies, there has been limited characterization of full-length major histocompatibility complex (MHC) class I immunogenetics of distinct geographic populations. Here, we identified 48 MHC class I cDNA nucleotide sequences in eleven Indonesian cynomolgus macaques, including 41 novel Mafa-A and Mafa-B sequences. We found seven MHC class I sequences in Indonesian macaques that were identical to MHC class I sequences identified in Malaysian or Mauritian macaques. Sharing of nucleotide sequences between these geographically distinct populations is also consistent with the hypothesis that Indonesia was a source of the Mauritian macaque population. In addition, we found that the Indonesian cDNA sequence Mafa-B7601 is identical throughout its peptide binding domain to Mamu-B03, an allele that has been associated with control of Simian immunodeficiency virus (SIV) viremia in Indian rhesus macaques. Overall, a better understanding of the MHC class I alleles present in Indonesian cynomolgus macaques improves their value as a model for disease research, and it better defines the biogeography of cynomolgus macaques throughout Southeast Asia.

Indexed as

AllelesGenes, MHC Class IAnimalsGenetics, PopulationIndonesiaMacaca fascicularis

Identifiers

PMID18504574
PMCPMC2612123
OpenAlexW2148044324

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.