Evidence map›Paper›PMID 18504424›Full record

SynthesisMolecular psychiatry2008

Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies.

J P Hamilton, M Siemer, I H Gotlib

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 230 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
230citing papers in PubMed, 8 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

230 citing papers in PubMed, 8 syntheses or guidelines pooled it, 500 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Deep brain stimulation for treatment-resistant depression: systematic review of clinical outcomes.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014
    Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Electroconvulsive Therapy-Induced Brain Structural and Functional Changes in Major Depressive Disorders: A Longitudinal Study.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Trial
  13. Trial
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

170 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

J P HamiltonDepartment of Psychology, Stanford University, Stanford, CA 94305, USA. paul.hamilton@stanford.edu
M Siemer
I H Gotlib
Stanford Medicine · USStanford University · USUniversity of Miami · US

Funding

Risk for Depression:Identifying and Altering Psychobiological MechanismsR01MH074849 · NIMH · STANFORD UNIVERSITY · PI GOTLIB, IAN H · 2006 to 2015
$6.2M
Neural and Behavioral Aspects of Information-Processing Biases in DepressionR01MH059259 · NIMH · STANFORD UNIVERSITY · PI GOTLIB, IAN H · 1999 to 2011
$5.9M
Real-time Localized Neuromodulation in Major DepressionF32MH079651 · NIMH · STANFORD UNIVERSITY · PI HAMILTON, J PAUL · 2007 to 2009
$159k
NIMH NIH HHS F32 MH079651NIMH NIH HHS MH059259NIMH NIH HHS MH074849NIMH NIH HHS MH079651NIMH NIH HHS R01 MH059259NIMH NIH HHS R01 MH074849
6 · The paper itself

Abstract

Major depressive disorder has been associated with volumetric abnormality in the amygdala. In this meta-analysis we examine results from magnetic resonance imaging volumetry studies of the amygdala in depression in order to assess both the nature of the relationship between depression and amygdala volume as well as the influence of extraexperimental factors that may account for significant variability in reported findings. We searched PubMed and ISI Web of Knowledge databases for articles published from 1985 to 2008 that used the wildcard terms 'Depress*' and 'Amygdal*' in the title, keywords or abstract. From the 13 studies that met inclusion criteria for our meta-analysis, we calculated aggregate effect size and heterogeneity estimates from amygdala volumetric data; we then used meta-regression to determine whether variability in specific extraexperimental factors accounted for variability in findings. The lack of a reliable difference in amygdala volume between depressed and never-depressed individuals was accounted for by a positive correlation between amygdala volume differences and the proportion of medicated depressed persons in study samples: whereas the aggregate effect size calculated from studies that included only medicated individuals indicated that amygdala volume was significantly increased in depressed relative to healthy persons, studies with only unmedicated depressed individuals showed a reliable decrease in amygdala volume in depression. These findings are consistent with a formulation in which an antidepressant-mediated increase in levels of brain-derived neurotrophic factor promotes neurogenesis and protects against glucocorticoid toxicity in the amygdala in medicated but not in unmedicated depression.

Indexed as

AmygdalaDatabases, FactualHumansMagnetic Resonance ImagingMajor Depressive Disorder

Identifiers

PMID18504424
PMCPMC2739676
OpenAlexW2129253531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.