ArticleHypertension (Dallas, Tex. : 1979)2008
Endothelial function and aminothiol biomarkers of oxidative stress in healthy adults.
Article in Hypertension (Dallas, Tex. : 1979), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 83 citations in OpenAlex.
- Antioxidant Effects of a Hydroxytyrosol-Based Pharmaceutical Formulation on Body Composition, Metabolic State, and Gene Expression: A Randomized Double-Blinded, Placebo-Controlled Crossover Trial.Oxidative medicine and cellular longevity · 2017Trial
- Postprandial cysteine/cystine redox potential in human plasma varies with meal content of sulfur amino acids.The Journal of nutrition · 2010Trial
- Selective Alterations of Thiol Redox Homeostasis and Antioxidant Enzyme Activity in Advanced Atherosclerosis.International journal of molecular sciences · 2026Article
- Effectiveness of the serum ratio of l-cysteine to glutathione for the prediction of cardiovascular events.Journal of clinical biochemistry and nutrition · 2025Article
- Analytical Methods for Assessing Thiol Antioxidants in Biological Fluids: A Review.Molecules (Basel, Switzerland) · 2024Review
- The Influence of Whole-Body Cryotherapy or Winter Swimming on the Activity of Antioxidant Enzymes.Biology · 2024Article
- Cysteine as a Multifaceted Player in Kidney, theMolecules (Basel, Switzerland) · 2022Review
- Glutathione deficiency in the pathogenesis of SARS-CoV-2 infection and its effects upon the host immune response in severe COVID-19 disease.Frontiers in microbiology · 2022Review
- Integrated molecular response of exposure to traffic-related pollutants in the US trucking industry.Environment international · 2022Article
- Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex.Antioxidants (Basel, Switzerland) · 2021Article
- High Plasma Cystine Levels Are Associated with Blood Pressure and Reversed by CPAP in Patients with Obstructive Sleep Apnea.Journal of clinical medicine · 2021Article
- The Potential Benefit of Monitoring Oxidative Stress and Inflammation in the Prevention of Non-Communicable Diseases (NCDs).Antioxidants (Basel, Switzerland) · 2020Review
- Decline in endothelial function across the menopause transition in healthy women is related to decreased estradiol and increased oxidative stress.GeroScience · 2020 · on this mapArticle
- Oxidative Stress and New Pathogenetic Mechanisms in Endothelial Dysfunction: Potential Diagnostic Biomarkers and Therapeutic Targets.Journal of clinical medicine · 2020Review
- Oxidative Stress Is Associated With Diastolic Dysfunction in Women With Ischemia With No Obstructive Coronary Artery Disease.Journal of the American Heart Association · 2020Article
- Cardiovascular Risk and Resilience Among Black Adults: Rationale and Design of the MECA Study.Journal of the American Heart Association · 2020Article
- Metabolomic assessment of exposure to near-highway ultrafine particles.Journal of exposure science & environmental epidemiology · 2019Article
- The mercapturomic profile of health and non-communicable diseases.High-throughput · 2019Review
- Amino Acid Profile of Synovial Fluid Following Intra-articular Ankle Fracture.Foot & ankle international · 2018Article
- Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study.Journal of neuroinflammation · 2018Observational
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Endothelial dysfunction is known to precede the development of atherosclerosis and results primarily from increased oxidative degradation of NO. We hypothesized that assessment of oxidative stress in the bloodstream will reliably predict endothelial function in healthy adults. A total of 124 healthy nonsmokers had endothelial function assessed using ultrasound measurement of brachial artery flow-mediated vasodilation. Plasma oxidative stress was estimated by measuring the levels of the reduced and oxidized forms of thiols, including glutathione (reduced glutathione and oxidized glutathione) and cysteine (cysteine and cystine), respectively, and the mixed disulfide. Among the traditional risk factors, there were significant and independent correlations between flow-mediated vasodilation and high-density lipoprotein level, body mass index, gender, and the Framingham risk score. Among the thiol markers, plasma cystine (r=-0.23; P=0.009) and the mixed disulfide (r=-0.23; P=0.01) levels correlated with endothelium-dependent but not endothelium-independent vasodilation, even after adjusting for the Framingham risk score and high-sensitivity C-reactive protein level. A higher level of oxidized metabolites was associated with worse endothelial function. In conclusion, the oxidative stress markers, cystine, and the mixed disulfide are independent predictors of endothelial function. These markers, in combination with the Framingham risk score, may help in the early identification of asymptomatic subjects with endothelial dysfunction who are at potentially increased risk for future atherosclerotic disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.