Voltage-gated Na channel selectivity: the role of the conserved domain III lysine residue.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

28 citing papers in PubMed.

1. Voltage-Gated Sodium Channel NaBiochemical genetics · 2026
   Article
2. The Chemistry and Biology of the Tetrodotoxin Natural Product Family.Angewandte Chemie (International ed. in English) · 2025
   Review
3. Role of Hydration and Amino Acid Interactions on the Ion Permeation Mechanism in the hNaBiochemistry · 2025
   Article
4. Molecular Dynamics Simulations of Ion Permeation in Human Voltage-Gated Sodium Channels.Journal of chemical theory and computation · 2023
   Article
5. Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels.Marine drugs · 2023
   Review
6. Construction of angstrom-scale ion channels with versatile pore configurations and sizes by metal-organic frameworks.Nature communications · 2023
   Article
7. Voltage gated sodium channels in cancer and their potential mechanisms of action.Channels (Austin, Tex.) · 2019
   Article
8. Comparison of permeation mechanisms in sodium-selective ion channels.Neuroscience letters · 2019
   Review
9. Ultrafast selective transport of alkali metal ions in metal organic frameworks with subnanometer pores.Science advances · 2018
   Article
10. Molecular Characterization of Voltage-Gated Sodium Channels and Their Relations with Paralytic Shellfish Toxin Bioaccumulation in the Pacific Oyster Crassostrea gigas.Marine drugs · 2017
    Article
11. Modeling the human NaDrug design, development and therapy · 2017
    Article
12. The hitchhiker's guide to the voltage-gated sodium channel galaxy.The Journal of general physiology · 2016
    Review
13. Lysine and the Na+/K+ Selectivity in Mammalian Voltage-Gated Sodium Channels.PloS one · 2016
    Article
14. Theoretical and simulation studies on voltage-gated sodium channels.Protein & cell · 2015
    Review
15. An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids.FEBS letters · 2015
    Article
16. From foe to friend: using animal toxins to investigate ion channel function.Journal of molecular biology · 2015
    Review
17. Predicting a double mutant in the twilight zone of low homology modeling for the skeletal muscle voltage-gated sodium channel subunit beta-1 (Nav1.4 β1).Computational and structural biotechnology journal · 2015
    Article
18. Animal toxins influence voltage-gated sodium channel function.Handbook of experimental pharmacology · 2014
    Review
19. A naturally occurring amino acid substitution in the voltage-dependent sodium channel selectivity filter affects channel gating.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2013
    Article
20. The mechanism of Na⁺/K⁺ selectivity in mammalian voltage-gated sodium channels based on molecular dynamics simulation.Biophysical journal · 2013
    Article

Corrections and comments

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Authors and funding

2 authors.

Funding

Abstract

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