ArticleThe Journal of general physiology2008
Prion protein attenuates excitotoxicity by inhibiting NMDA receptors.
Article in The Journal of general physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The prion protein is required for normal responses to light stimuli by photoreceptors and bipolar cells.iScience · 2024Article
- Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination.Molecular neurodegeneration · 2022Review
- A soluble derivative of PrPThe Journal of biological chemistry · 2020Article
- Prions, prionoids and protein misfolding disorders.Nature reviews. Genetics · 2018Review
- Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex.Journal of neurochemistry · 2018Article
- Role of hypoxia‑mediated cellular prion protein functional change in stem cells and potential application in angiogenesis (Review).Molecular medicine reports · 2017Article
- Functions of the cellular prion protein, the end of Moore's law, and Ockham's razor theory.Prion · 2016Article
- In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution.Frontiers in neuroscience · 2016Article
- Involvement of PrP(C) in kainate-induced excitotoxicity in several mouse strains.Scientific reports · 2015Article
- Hematological shift in goat kids naturally devoid of prion protein.Frontiers in cell and developmental biology · 2015Article
- Prnp gene and cerebellum volume in patients with refractory mesial temporal lobe epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
- The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6.The Journal of biological chemistry · 2013Article
- Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D.Neuropharmacology · 2013Article
- Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators.Neurochemistry international · 2012Review
- Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors.Neurochemistry international · 2012Article
- Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes.International journal of Alzheimer's disease · 2010Article
- A novel family of negative and positive allosteric modulators of NMDA receptors.The Journal of pharmacology and experimental therapeutics · 2010Article
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11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well established that misfolded forms of cellular prion protein (PrP [PrPC]) are crucial in the genesis and progression of transmissible spongiform encephalitis, whereas the function of native PrPC remains incompletely understood. To determine the physiological role of PrPC, we examine the neurophysiological properties of hippocampal neurons isolated from PrP-null mice. We show that PrP-null mouse neurons exhibit enhanced and drastically prolonged N-methyl-D-aspartate (NMDA)-evoked currents as a result of a functional upregulation of NMDA receptors (NMDARs) containing NR2D subunits. These effects are phenocopied by RNA interference and are rescued upon the overexpression of exogenous PrPC. The enhanced NMDAR activity results in an increase in neuronal excitability as well as enhanced glutamate excitotoxicity both in vitro and in vivo. Thus, native PrPC mediates an important neuroprotective role by virtue of its ability to inhibit NR2D subunits.
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18504311What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.