Trial reportBMJ (Clinical research ed.)2008
Determination of pH or lactate in fetal scalp blood in management of intrapartum fetal distress: randomised controlled multicentre trial.
Trial report in BMJ (Clinical research ed.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 155 citations in OpenAlex.
- Fetal scalp stimulation for assessing fetal well-being during labour.The Cochrane database of systematic reviews · 2023Pooled it
- Effectiveness of intrapartum fetal surveillance to improve maternal and neonatal outcomes: a systematic review and network meta-analysis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2021Pooled it
- Intrapartum fetal scalp lactate sampling for fetal assessment in the presence of a non-reassuring fetal heart rate trace.The Cochrane database of systematic reviews · 2015Pooled it
- Protocol for a randomised controlled trial of fetal scalp blood lactate measurement to reduce caesarean sections during labour: the Flamingo trial [ACTRN12611000172909].BMC pregnancy and childbirth · 2015Trial
- Fetal heart rate patterns associated with acidemia at fetal blood sampling during labor-An observational study.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Toward implementation of lactate compared with pH in fetal scalp blood sampling during labor: A clinical comparative single-center study.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Serial Lactate in Clinical Medicine - A Narrative Review.Journal of intensive care medicine · 2026Review
- Twenty-year trends in fetal scalp-blood sampling and birth outcomes: A single-center retrospective cohort study of 40 309 women in labor.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Validation and proposal of a clinical intervention cutoff in fetal scalp blood for the point-of care-lactate meter StatStripActa obstetricia et gynecologica Scandinavica · 2025Observational
- Frequency of fetal blood sampling, delivery mode and neonatal outcome after revised CTG-classification and updated lactate meter in Sweden: An observational study.Acta obstetricia et gynecologica Scandinavica · 2025Observational
- Are we ready for widespread implementation of lactate POCT in fetal blood sampling? An analytical and clinical verification of the novel statstrip POCT analyzer.Practical laboratory medicine · 2024Article
- Trends in Term Intrapartum Stillbirth in Norway.JAMA network open · 2023Article
- Neonatal outcomes associated with time from a high fetal blood lactate concentration to operative delivery.Acta obstetricia et gynecologica Scandinavica · 2023Observational
- MR imaging and outcome in neonatal HIBD models are correlated with sex: the value of diffusion tensor MR imaging and diffusion kurtosis MR imaging.Frontiers in neuroscience · 2023Article
- A before and after study of the impact on obstetric and perinatal outcomes following the introduction of an educational package of fetal heart rate monitoring education coupled with umbilical artery lactate sampling in a low resource setting labor ward in South Africa.BMC pregnancy and childbirth · 2019Article
- Learn from Your Elders: Developmental Biology Lessons to Guide Maturation of Stem Cell-Derived Cardiomyocytes.Pediatric cardiology · 2019Review
- Sensors for Fetal Hypoxia and Metabolic Acidosis: A Review.Sensors (Basel, Switzerland) · 2018Review
- Infant outcome at four years of age after intrapartum sampling of scalp blood lactate for fetal assessment. A cohort study.PloS one · 2018Article
- Reference values for fetal tissue velocity imaging and a new approach to evaluate fetal myocardial function.Cardiovascular ultrasound · 2013Article
- A pilot study to determine the feasibility of collecting amniotic fluid samples from women during labour and measuring amniotic fluid lactate at point of care.BMC research notes · 2013Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the effectiveness of pH analysis of fetal scalp blood compared with lactate analysis in identifying hypoxia in labour to prevent acidaemia at birth.
designRandomised controlled multicentre trial.
settingLabour wards.
participantsWomen with a singleton pregnancy, cephalic presentation, gestational age >or=34 weeks, and clinical indication for fetal scalp blood sampling.
interventionsStandard pH analysis (n=1496) or lactate analysis (n=1496) with an electrochemical microvolume (5 mul) test strip device. The cut-off levels for intervention were pH <7.21 and lactate >4.8 mmol/l, respectively.
main outcome measureMetabolic acidaemia (pH <7.05 and base deficit >12 mmol/l) or pH <7.00 in cord artery blood.
resultsMetabolic acidaemia occurred in 3.2% in the lactate group and in 3.6% in the pH group (relative risk 0.91, 95% confidence interval 0.61 to 1.36). pH <7.00 occurred in 1.5% in the lactate group and in 1.8% in the pH group (0.84, 0.47 to 1.50). There was no significant difference in Apgar scores <7 at 5 minutes (1.15, 0.76 to 1.75) or operative deliveries for fetal distress (1.02, 0.93 to 1.11).
conclusionThere were no significant differences in rate of acidaemia at birth after use of lactate analysis or pH analysis of fetal scalp blood samples to determine hypoxia during labour.
trial registrationISRCT No 1606064.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.