ArticleThe Journal of pharmacology and experimental therapeutics2008
Brain regional differences in the effect of ethanol on GABA release from presynaptic terminals.
Article in The Journal of pharmacology and experimental therapeutics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 42 citations in OpenAlex.
- Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.Alcoholism, clinical and experimental research · 2011Trial
- Ethanol induces persistent potentiation of 5-HTNeuropharmacology · 2021Article
- Multiple sources of internal calcium stores mediate ethanol-induced presynaptic inhibitory GABA release in the central nucleus of the amygdala in mice.Psychopharmacology · 2020Article
- Forensic appraisal of death due to acute alcohol poisoning: three case reports and a literature review.Forensic sciences research · 2019Article
- Effects of Acute Alcohol Exposure on Layer 5 Pyramidal Neurons of Juvenile Mice.Cellular and molecular neurobiology · 2018Article
- Examining the effects of alcohol on GABAAlcohol (Fayetteville, N.Y.) · 2018Article
- The Cerebellar GABAHandbook of experimental pharmacology · 2018Article
- Review
- Effects of acute alcohol on excitability in the CNS.Neuropharmacology · 2017Review
- Very low concentrations of ethanol suppress excitatory synaptic transmission in rat visual cortex.The European journal of neuroscience · 2017Article
- Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?Frontiers in cellular neuroscience · 2016Review
- Mini-Review: Effects of Ethanol on GABAA Receptor-Mediated Neurotransmission in the Cerebellar Cortex--Recent Advances.Cerebellum (London, England) · 2015Review
- Innate immune factors modulate ethanol interaction with GABAergic transmission in mouse central amygdala.Brain, behavior, and immunity · 2014Article
- Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrations.Journal of neurochemistry · 2014Article
- Acute and chronic effects of ethanol on learning-related synaptic plasticity.Alcohol (Fayetteville, N.Y.) · 2014Review
- Opposite actions of alcohol on tonic GABA(A) receptor currents mediated by nNOS and PKC activity.Nature neuroscience · 2013Article
- Primate cerebellar granule cells exhibit a tonic GABAAR conductance that is not affected by alcohol: a possible cellular substrate of the low level of response phenotype.Frontiers in neural circuits · 2013Article
- Ethanol Activation of Protein Kinase A Regulates GABA(A) Receptor Subunit Expression in the Cerebral Cortex and Contributes to Ethanol-Induced Hypnosis.Frontiers in neuroscience · 2012Article
- Neurosteroid influences on sensitivity to ethanol.Frontiers in endocrinology · 2012Article
- Ethanol modulation of synaptic plasticity.Neuropharmacology · 2011Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Whereas ethanol has behavioral actions consistent with increased GABAergic function, attempts to demonstrate a direct enhancement of GABA-gated currents by ethanol have produced mixed results. Recent work has suggested that a part of the GABAergic profile of ethanol may result from enhanced GABA release from presynaptic terminals. The present study examines the effect of ethanol on GABA release in several brain regions to assess the regional nature of ethanol-induced GABA release. Whole-cell voltage clamp recording of spontaneous inhibitory postsynaptic currents (sIPSCs) from mechanically dissociated neurons and miniature inhibitory postsynaptic currents (mIPSCs) and paired-pulse ratio (PPR) from a slice preparation were used to quantify GABA release. Ethanol produced a concentration-dependent increase in the frequency of sIPSCs recorded from mechanically dissociated cerebellar Purkinje neurons and mIPSCs from substantia nigra neurons without having an effect on sIPSCs recorded from lateral septal or cerebrocortical neurons. This regional difference in the effect of ethanol on GABA release was confirmed with PPR recording from brain slices. These data indicate that ethanol can act on presynaptic terminals to increase GABA release in some brain regions while having little or no effect on GABA release in others. This regional difference is consistent with earlier in vivo studies in which ethanol affected neural activity and sensitivity to GABA in some, but not all, brain sites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.