ArticleApplied and environmental microbiology2008
Genetic homogeneity of Clostridium botulinum type A1 strains with unique toxin gene clusters.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
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- Complete Genome Sequence of Clostridium botulinum CJ0611A1, a Type A(B) Isolate Associated with an International Outbreak of Botulism from Commercial Carrot Juice.Microbiology resource announcements · 2021Article
- ClosingFrontiers in microbiology · 2020Article
- Dietary Supplementation with Trihexanoin Enhances Intestinal Function of Weaned Piglets.International journal of molecular sciences · 2018Article
- Pulsotype Diversity of Clostridium botulinum Strains Containing Serotypes A and/or B Genes.Foodborne pathogens and disease · 2017Article
- Finished Whole-Genome Sequences of TwoGenome announcements · 2017Article
- Historical and current perspectives on Clostridium botulinum diversity.Research in microbiology · 2015Review
- Genomic sequences of six botulinum neurotoxin-producing strains representing three clostridial species illustrate the mobility and diversity of botulinum neurotoxin genes.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Article
- First report of an infant botulism case due to Clostridium botulinum type Af.Journal of clinical microbiology · 2015Article
- Immunoprecipitation of native botulinum neurotoxin complexes from Clostridium botulinum subtype A strains.Applied and environmental microbiology · 2015Article
- Draft Genome Sequence of Bivalent Clostridium botulinum Strain IBCA10-7060, Encoding Botulinum Neurotoxin B and a New FA Mosaic Type.Genome announcements · 2014Article
- Identification and genetic characterization of Clostridium botulinum serotype A strains from commercially pasteurized carrot juice.Food microbiology · 2014Article
- Genetic characterization and comparison of Clostridium botulinum isolates from botulism cases in Japan between 2006 and 2011.Applied and environmental microbiology · 2014Article
- Functional characterisation of germinant receptors in Clostridium botulinum and Clostridium sporogenes presents novel insights into spore germination systems.PLoS pathogens · 2014Article
- Three enzymatically active neurotoxins of Clostridium botulinum strain Af84: BoNT/A2, /F4, and /F5.Analytical chemistry · 2014Article
- Whole-genome single-nucleotide-polymorphism analysis for discrimination of Clostridium botulinum group I strains.Applied and environmental microbiology · 2014Article
- Article
- Genetic diversity among Clostridium botulinum strains harboring bont/A2 and bont/A3 genes.Applied and environmental microbiology · 2012Article
- Subtyping botulinum neurotoxins by sequential multiple endoproteases in-gel digestion coupled with mass spectrometry.Analytical chemistry · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
A group of five clonally related Clostridium botulinum type A strains isolated from different sources over a period of nearly 40 years harbored several conserved genetic properties. These strains contained a variant bont/A1 with five nucleotide polymorphisms compared to the gene in C. botulinum strain ATCC 3502. The strains also had a common toxin gene cluster composition (ha-/orfX+) similar to that associated with bont/A in type A strains containing an unexpressed bont/B [termed A(B) strains]. However, bont/B was not identified in the strains examined. Comparative genomic hybridization demonstrated identical genomic content among the strains relative to C. botulinum strain ATCC 3502. In addition, microarray data demonstrated the absence of several genes flanking the toxin gene cluster among the ha-/orfX+ A1 strains, suggesting the presence of genomic rearrangements with respect to this region compared to the C. botulinum ATCC 3502 strain. All five strains were shown to have identical flaA variable region nucleotide sequences. The pulsed-field gel electrophoresis patterns of the strains were indistinguishable when digested with SmaI, and a shift in the size of at least one band was observed in a single strain when digested with XhoI. These results demonstrate surprising genomic homogeneity among a cluster of unique C. botulinum type A strains of diverse origin.
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