ArticleBiophysical journal2008
Clathrin triskelia show evidence of molecular flexibility.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Article
- Interface flexibility controls the nucleation and growth of supramolecular networks.Nature chemistry · 2025Article
- Numerical simulation of endocytosis: Viscous flow driven by membranes with non-uniformly distributed curvature-inducing molecules.Journal of computational physics · 2016Article
- Mechanisms shaping cell membranes.Current opinion in cell biology · 2014Review
- Micellization model for the polymerization of clathrin baskets.The Journal of chemical physics · 2013Article
- Nuclear localization of clathrin involves a labile helix outside the trimerization domain.FEBS letters · 2013Article
- Systems biology and physical biology of clathrin-mediated endocytosis.Integrative biology : quantitative biosciences from nano to macro · 2011Review
- AFM visualization of clathrin triskelia under fluid and in air.FEBS letters · 2010Article
- Three-dimensional structure and flexibility of a membrane-coating module of the nuclear pore complex.Nature structural & molecular biology · 2009Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The clathrin triskelion, which is a three-legged pinwheel-shaped heteropolymer, is a major component in the protein coats of certain post-Golgi and endocytic vesicles. At low pH, or at physiological pH in the presence of assembly proteins, triskelia will self-assemble to form a closed clathrin cage, or "basket". Recent static light scattering and dynamic light scattering studies of triskelia in solution showed that an individual triskelion has an intrinsic pucker similar to, but differing from, that inferred from a high resolution cryoEM structure of a triskelion in a clathrin basket. We extend the earlier solution studies by performing small-angle neutron scattering (SANS) experiments on isolated triskelia, allowing us to examine a higher q range than that probed by static light scattering. Results of the SANS measurements are consistent with the light scattering measurements, but show a shoulder in the scattering function at intermediate q values (0.016 A(-1)), just beyond the Guinier regime. This feature can be accounted for by Brownian dynamics simulations based on flexible bead-spring models of a triskelion, which generate time-averaged scattering functions. Calculated scattering profiles are in good agreement with the experimental SANS profiles when the persistence length of the assumed semiflexible triskelion is close to that previously estimated from the analysis of electron micrographs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.