ArticleBiophysical journal2008
Lipid bilayer structure determined by the simultaneous analysis of neutron and X-ray scattering data.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 215 papers.
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Who cites it
215 citing papers in PubMed, 594 citations in OpenAlex.
- Article
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- Decoding the Role of Lipid Metabolism and Membrane Dynamics in Melanoma.International journal of molecular sciences · 2026Review
- Alteration of the Lipid Bilayer Structure by MgLangmuir : the ACS journal of surfaces and colloids · 2026Article
- Investigating Peptide-Lipid Membrane Interactions Using Small Angle X-Ray and Neutron Scattering.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Helical sensors of membrane saturation: Changes in orientation and curvature preference.Biophysical journal · 2025Article
- Structural pores not required: Antimicrobial peptides induce ion permeabilization of lipid membranes through transient water channels.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Development of Transferable Coarse-Grained Lipid Models with Optimized Structural and Elastic Membrane Properties.Journal of chemical theory and computation · 2025Article
- Quantifying the Thresholds of the Phospholipid Surface Density for Nonspecific Protein Adsorption and Desorption at the Triacylglycerol/Water Interface.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Impact of lipid asymmetry on membrane biophysical properties: Insights from molecular dynamics simulations.Quantitative biology (Beijing, China) · 2025Article
- Mesoscopic Structure of Lipid Nanoparticles Studied by Small-Angle X-Ray Scattering: A Spherical Core-Triple Shell Model Analysis.Membranes · 2025Article
- µ-Raman Spectroscopic Temperature Dependence Study of Biomimetic Lipid 1,2-Diphytanoyl-sn-glycero-3-phosphocholine.Biomimetics (Basel, Switzerland) · 2025Article
- Bilayer-Forming Lipids Enhance Archaeal Monolayer Membrane Stability.International journal of molecular sciences · 2025Article
- A quantitative analysis of ligand binding at the protein-lipid bilayer interface.Communications chemistry · 2025Article
- Article
- The Importance of Bilayer Asymmetry in Biological Membranes: Insights from Model Membranes.Membranes · 2025Review
- Neutron spin echo shows pHLIP is capable of retarding membrane thickness fluctuations.Biochimica et biophysica acta. Biomembranes · 2024Article
- Sterol-lipids enable large-scale, liquid-liquid phase separation in bilayer membranes of only two components.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Influence of the Water Model on the Structure and Interactions of the GPR40 Protein with the Lipid Membrane and the Solvent: Rigid versus Flexible Water Models.Journal of chemical theory and computation · 2024Article
155 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 7 institutions in 3 countries.
Funding
Abstract
Quantitative structures were obtained for the fully hydrated fluid phases of dioleoylphosphatidylcholine (DOPC) and dipalmitoylphosphatidylcholine (DPPC) bilayers by simultaneously analyzing x-ray and neutron scattering data. The neutron data for DOPC included two solvent contrasts, 50% and 100% D(2)O. For DPPC, additional contrast data were obtained with deuterated analogs DPPC_d62, DPPC_d13, and DPPC_d9. For the analysis, we developed a model that is based on volume probability distributions and their spatial conservation. The model's design was guided and tested by a DOPC molecular dynamics simulation. The model consistently captures the salient features found in both electron and neutron scattering density profiles. A key result of the analysis is the molecular surface area, A. For DPPC at 50 degrees C A = 63.0 A(2), whereas for DOPC at 30 degrees C A = 67.4 A(2), with estimated uncertainties of 1 A(2). Although A for DPPC agrees with a recently reported value obtained solely from the analysis of x-ray scattering data, A for DOPC is almost 10% smaller. This improved method for determining lipid areas helps to reconcile long-standing differences in the values of lipid areas obtained from stand-alone x-ray and neutron scattering experiments and poses new challenges for molecular dynamics simulations.
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