ArticleThe Journal of biological chemistry2008
Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review.Molecular medicine (Cambridge, Mass.) · 2023Pooled it
- The heme-regulated inhibitor kinase Hri1 is activated in response to aminolevulinic acid deficiency in Schizosaccharomyces pombe.PLoS genetics · 2025Article
- A connection between the ribosome and two S. pombe tRNA modification mutants subject to rapid tRNA decay.PLoS genetics · 2024Article
- The life and times of a tRNA.RNA (New York, N.Y.) · 2023Review
- Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.Nucleic acids research · 2022Article
- Origin of translational control by eIF2α phosphorylation: insights from genome-wide translational profiling studies in fission yeast.Current genetics · 2021Review
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- Article
- Gcn2 eIF2α kinase mediates combinatorial translational regulation through nucleotide motifs and uORFs in target mRNAs.Nucleic acids research · 2020Article
- Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences.PLoS genetics · 2020Article
- eIF3a Regulation of NHEJ Repair Protein Synthesis and Cellular Response to Ionizing Radiation.Frontiers in cell and developmental biology · 2020Article
- The Interaction between the Ribosomal Stalk Proteins and Translation Initiation Factor 5B Promotes Translation Initiation.Molecular and cellular biology · 2018Article
- Lack of 2'-O-methylation in the tRNA anticodon loop of two phylogenetically distant yeast species activates the general amino acid control pathway.PLoS genetics · 2018Article
- General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Activation of Gcn2 in response to different stresses.PloS one · 2017Article
- A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism.Cell reports · 2016Article
- Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e.Genes & development · 2014Article
- A stress-activated, p38 mitogen-activated protein kinase-ATF/CREB pathway regulates posttranscriptional, sequence-dependent decay of target RNAs.Molecular and cellular biology · 2013Article
- Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast.The Journal of biological chemistry · 2013Article
- Random mutagenesis of yeast 25S rRNA identify bases critical for 60S subunit structural integrity and function.Translation (Austin, Tex.) · 2013Article
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
int-6 is one of the frequent integration sites for mouse mammary tumor viruses. Although its product is the e-subunit of translation initiation factor eIF3, other evidence indicates that it interacts with proteasomes or other proteins to regulate protein stability. Here we report that the fission yeast int6(+) is required for overcoming stress imposed by histidine starvation, using the drug 3-aminotriazole (3AT). Microarray and complementary Northern studies using wild-type, int6Delta or gcn2Delta mutants indicate that 3AT-treated wild-type yeast induces core environmental stress response (CESR) genes in addition to typical general amino acid control (GAAC) genes whose transcription depends on the eIF2 kinase, Gcn2. In agreement with this, Sty1 MAPK and its target transcription factor Atf1, which signal the CESR, are required for overcoming 3AT-induced starvation. We find that Int6 is required for maintaining the basal level of Atf1 and for rapid transcriptional activation of the CESR on 3AT-insult. Pulse labeling experiments indicate that int6Delta significantly slows down de novo protein synthesis. Moreover, Atf1 protein half-life was reduced in int6Delta cells. These effects would account for the compromised Atf1 activity on 3AT-induced stress. Thus, the robust protein synthesis promoted by intact eIF3 appears to be a part of the requisites for sound Sty1 MAPK-dependent signaling governed by the activity of the Atf1 transcription factor.
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