Evidence map›Paper›PMID 18502633›Full record

ReviewCurrent opinion in cell biology2008

Multivesicular bodies: co-ordinated progression to maturity.

Philip G Woodman, Clare E Futter

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 196 citations in OpenAlex.

  1. Review
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  12. Nonvesicular cholesterol transport in physiology.The Journal of clinical investigation · 2025
    Review
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Philip G WoodmanFaculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom.
Clare E Futter
University College London · GBUniversity of Manchester · GB

Funding

Biotechnology and Biological Sciences Research Council BB/512929/1Biotechnology and Biological Sciences Research Council BB/D011841Biotechnology and Biological Sciences Research Council BB/E019919/1Cancer Research UK C20675Medical Research Council G0001128Medical Research Council G9722026Wellcome Trust 078304
6 · The paper itself

Abstract

Multivesicular endosomes/bodies (MVBs) sort endocytosed proteins to different destinations. Many lysosomally directed membrane proteins are sorted onto intralumenal vesicles, whilst recycling proteins remain on the perimeter membrane from where they are removed via tubular extensions. MVBs move to the cell centre during this maturation process and, when all recycling proteins have been removed, fuse with lysosomes. Recent advances have identified endosomal-sorting complex required for transport (ESCRT)-dependent and ESCRT-independent pathways in intralumenal vesicle formation and mechanisms for sorting recycling cargo into tubules. Cytoskeletal motors, through interactions with these machineries and by regulating MVB movement, help to co-ordinate events leading to a mature, fusion-competent MVB.

Indexed as

AnimalsBiological TransportEndosomesHumansTransport VesiclesVesicular Transport ProteinsVesicular Transport Proteins

Identifiers

PMID18502633
PMCPMC2577128
OpenAlexW2031136388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.