Trial reportAmbulatory pediatrics : the official journal of the Ambulatory Pediatric Association
Children's cognitive-behavioral functioning at age 6 and 7: prenatal drug exposure and caregiving environment.
Trial report in Ambulatory pediatrics : the official journal of the Ambulatory Pediatric Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A Meta-Analysis of Stressors from the Total Environment Associated with Children's General Cognitive Ability.International journal of environmental research and public health · 2020Pooled it
- A Systematic Review and Meta-Analysis Investigating the Relationship between Exposures to Chemical and Non-Chemical Stressors during Prenatal Development and Childhood Externalizing Behaviors.International journal of environmental research and public health · 2020Pooled it
- Cognitive and Motor Outcomes of Children With Prenatal Opioid Exposure: A Systematic Review and Meta-analysis.JAMA network open · 2019Pooled it
- Contributions of a Child's Built, Natural, and Social Environments to Their General Cognitive Ability: A Systematic Scoping Review.PloS one · 2016Pooled it
- Home visits during pregnancy and after birth for women with an alcohol or drug problem.The Cochrane database of systematic reviews · 2012Pooled it
- The effect of prenatal drug exposure and caregiving context on children's performance on a task of sustained visual attention.Journal of developmental and behavioral pediatrics : JDBP · 2008Trial
- Early emotional caregiving environment and associations with memory performance and hippocampal volume in adolescents with prenatal drug exposure.Frontiers in behavioral neuroscience · 2023Article
- Prenatal exposure to opioids and neurodevelopment in infancy and childhood: A systematic review.Frontiers in pediatrics · 2023Review
- Association Between Prenatal Opioid Exposure and Neurodevelopmental Outcomes in Early Childhood: A Retrospective Cohort Study.Drug safety · 2021Article
- Prenatal Exposures Are Associated With Worse Neurodevelopmental Outcomes in Infants With Neonatal Opioid Withdrawal Syndrome.Frontiers in pediatrics · 2020Article
- Children with chronic lung diseases have cognitive dysfunction as assessed by event-related potential (auditory P300) and Stanford-Binet IQ (SB-IV) test.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Relations among prospective memory, cognitive abilities, and brain structure in adolescents who vary in prenatal drug exposure.Journal of experimental child psychology · 2014Article
- Prenatal drug exposure moderates the association between stress reactivity and cognitive function in adolescence.Developmental neuroscience · 2014Article
- Prevalence and clinical correlates of explosive outbursts in Tourette syndrome.Psychiatry research · 2013Article
- Pre-placement risk and longitudinal cognitive development for children adopted from foster care.Child welfare · 2013Article
- Memory ability and hippocampal volume in adolescents with prenatal drug exposure.Neurotoxicology and teratology · 2012Article
- Prenatal drug exposure and peer victimization in early adolescence: testing childhood anxiety/depression and aggression as possible mediators.Journal of developmental and behavioral pediatrics : JDBP · 2012Article
- Review
- Prenatal drug exposure to illicit drugs alters working memory-related brain activity and underlying network properties in adolescence.Neurotoxicology and teratologyArticle
- Level of intrauterine cocaine exposure and neuropsychological test scores in preadolescence: subtle effects on auditory attention and narrative memory.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThe aim of this study was to examine how prenatal drug exposure (PDE) and caregiving environment relate to cognitive, academic, and behavioral performance at ages 6 and 7.
methodsA longitudinal follow-up was conducted of 111 children with PDE and a community cohort of 62 non-drug-exposed children (N = 173). Children completed standardized tests of cognition (Stanford-Binet Intelligence Scales, Fourth Edition [SB-IV]) and academic performance (Wide Range Achievement Test 3). Caregivers completed ratings of child behavior problems (Child Behavior Checklist [CBCL]). Multivariate analyses were conducted, adjusting for gender, prenatal tobacco exposure, number of caregiver placement changes, and 3 caregiver variables assessed at age 7, including depressive symptoms, employment status, and public assistance status.
resultsAfter adjusting for perinatal and environmental variables, there were no significant exposure-group differences in cognition, academic performance, or behavior problems. In comparison with males, females had higher scores on overall IQ and 4 of 8 SB-IV subtests, fewer caregiver-reported attention and aggression problems, and higher reading achievement scores. There were no significant gender-by-group interactions.
conclusionWhen analyses were adjusted for perinatal and environmental variables, most associations between PDE and cognitive-behavioral functioning were attenuated. Regardless of drug exposure history, males performed more poorly than females on multiple cognitive-behavioral indices. Both exposed and nonexposed children were from low-income families and obtained scores substantially below normative expectations.
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