ArticleBMC infectious diseases2008
Healthcare-associated infections in pediatric cancer patients: results of a prospective surveillance study from university hospitals in Germany and Switzerland.
Article in BMC infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Interventions other than anticoagulants and systemic antibiotics for prevention of central venous catheter-related infections in children with cancer.The Cochrane database of systematic reviews · 2010Pooled it
- Incidence of acute kidney injury among pediatric hematology/oncology patients receiving vancomycin in combination with piperacillin/tazobactam or cefepime.Pediatric blood & cancer · 2019Trial
- A prospective multicenter study of microbiologically defined infections in pediatric cancer patients with fever and neutropenia: Swiss Pediatric Oncology Group 2003 fever and neutropenia study.The Pediatric infectious disease journal · 2014Trial
- Outcome of Pediatric, Adolescent, and Young Adult Oncology Patients With Non-neutropenic Fever: A Scoping Review of the Literature.Current pediatric reviews · 2026Article
- Feasibility, efficacy, and safety of animal-assisted activities with visiting dogs in inpatient pediatric oncology.World journal of pediatrics : WJP · 2024Article
- Diagnostic Stewardship in the Pediatric Intensive Care Unit.Infectious disease clinics of North America · 2022Review
- Numbers and narratives: how qualitative methods can strengthen the science of paediatric antimicrobial stewardship.JAC-antimicrobial resistance · 2022Review
- Oncology during the COVID-19 pandemic: challenges, dilemmas and the psychosocial impact on cancer patients.Oncology letters · 2020Review
- Antimicrobial-resistant pathogens associated with pediatric healthcare-associated infections: Summary of data reported to the National Healthcare Safety Network, 2015-2017.Infection control and hospital epidemiology · 2020Article
- Multiple sequence types responsible for healthcare-associated Acinetobacter baumannii dissemination in a single centre in Egypt.BMC infectious diseases · 2019Article
- Antibiotic-Resistant Septicemia in Pediatric Oncology Patients Associated with Post-Therapeutic Neutropenic Fever.Antibiotics (Basel, Switzerland) · 2019Review
- High Rates of Community and Hospital Acquired Infections in Patients with Cellular Immunodeficiencies.Journal of clinical immunology · 2018Article
- Investigation of Clostridium difficile ribotypes in symptomatic patients of a German pediatric oncology center.European journal of pediatrics · 2018Article
- Evaluation of bloodstream infections, Clostridium difficile infections, and gut microbiota in pediatric oncology patients.PloS one · 2018Article
- The role of Clostridium difficile in the paediatric and neonatal gut - a narrative review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Review
- The Centers for Disease Control and Prevention definition of mucosal barrier injury-associated bloodstream infection improves accurate detection of preventable bacteremia rates at a pediatric cancer center in a low- to middle-income country.American journal of infection control · 2016Article
- Surveillance of bloodstream infections in pediatric cancer centers - what have we learned and how do we move on?GMS hygiene and infection control · 2016Review
- Bloodstream infection in paediatric cancer centres--leukaemia and relapsed malignancies are independent risk factors.European journal of pediatrics · 2015Article
- Impact of a modified Broviac maintenance care bundle on bloodstream infections in paediatric cancer patients.GMS hygiene and infection control · 2015Article
- Bacterial bloodstream infections and antimicrobial susceptibility pattern in pediatric hematology/oncology patients after anticancer chemotherapy.Infection and drug resistance · 2014Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPediatric cancer patients face an increased risk of healthcare-associated infection (HAI). To date, no prospective multicenter studies have been published on this topic.
methodsProspective multicenter surveillance for HAI and nosocomial fever of unknown origin (nFUO) with specific case definitions and standardized surveillance methods.
results7 pediatric oncology centers (university facilities) participated from April 01, 2001 to August 31, 2005. During 54,824 days of inpatient surveillance, 727 HAIs and nFUOs were registered in 411 patients. Of these, 263 (36%) were HAIs in 181 patients, for an incidence density (ID) (number of events per 1,000 inpatient days) of 4.8 (95% CI 4.2 to 5.4; range 2.4 to 11.7; P < 0.001), and 464 (64%) were nFUO in 230 patients. Neutropenia at diagnosis correlated significantly with clinical severity of HAI. Of the 263 HAIs, 153 (58%) were bloodstream infections (BSI). Of the 138 laboratory-confirmed BSIs, 123 (89%) were associated with use of a long-term central venous catheter (CVAD), resulting in an overall ID of 2.8 per 1,000 utilization days (95% CI 2.3 to 3.3). The ID was significantly lower in Port-type than in Hickman-type CVADs. The death of 8 children was related to HAI, including six cases of aspergillosis. The attributable mortality was 3.0% without a significant association to neutropenia at time of NI diagnosis.
conclusionOur study confirmed that pediatric cancer patients are at an increased risk for specific HAIs. The prospective surveillance of HAI and comparison with cumulative multicenter results are indispensable for targeted prevention of these adverse events of anticancer treatment.
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