ArticleJournal of the International Society of Sports Nutrition2006
The regulation and expression of the creatine transporter: a brief review of creatine supplementation in humans and animals.
Article in Journal of the International Society of Sports Nutrition, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- The effects of phosphocreatine disodium salts plus blueberry extract supplementation on muscular strength, power, and endurance.Journal of the International Society of Sports Nutrition · 2021Trial
- Creatine electrolyte supplement improves anaerobic power and strength: a randomized double-blind control study.Journal of the International Society of Sports Nutrition · 2019Trial
- Creatine-electrolyte supplementation improves repeated sprint cycling performance: A double blind randomized control study.Journal of the International Society of Sports Nutrition · 2018Trial
- Creatine supplementation and respiratory muscle function in health and disease: translational insights from human to mouse.ERJ open research · 2026Article
- Optimal neuromuscular performance requires motor neuron phosphagen kinases.The Journal of physiology · 2026Article
- Performance Responses and Fillet Quality of Rainbow Trout (Animals : an open access journal from MDPI · 2025Article
- Dietary creatine nitrate enhances muscle creatine loading and delays postmortem glycolysis of broilers that experienced preslaughter transport.Journal of animal science · 2022Article
- Evaluation of chronic toxicity of cyclocreatine in beagle dogs after oral gavage administration for up to 23 weeks.Toxicology and applied pharmacology · 2021Article
- Beneficial Impact of Semicarbazide-Sensitive Amine Oxidase Inhibition on the Potential Cytotoxicity of Creatine Supplementation in Type 2 Diabetes Mellitus.Molecules (Basel, Switzerland) · 2020Review
- Fenugreek increases insulin-stimulated creatine content in L6C11 muscle myotubes.European journal of nutrition · 2017Article
- Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults.Nutrition journal · 2014Article
- Urinary creatine at rest and after repeated sprints in athletes: a pilot study.Biology of sport · 2014Article
- Creatine, L-carnitine, and ω3 polyunsaturated fatty acid supplementation from healthy to diseased skeletal muscle.BioMed research international · 2014Article
- Creatine supplementation with specific view to exercise/sports performance: an update.Journal of the International Society of Sports Nutrition · 2012Article
- The effect of nitric-oxide-related supplements on human performance.Sports medicine (Auckland, N.Z.) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Creatine monohydrate has become one of the most popular ergogenic sport supplements used today. It is a nonessential dietary compound that is both endogenously synthesized and naturally ingested through diet. Creatine ingested through supplementation has been observed to be absorbed into the muscle exclusively by means of a creatine transporter, CreaT1. The major rationale of creatine supplementation is to maximize the increase within the intracellular pool of total creatine (creatine + phosphocreatine). There is much evidence indicating that creatine supplementation can improve athletic performance and cellular bioenergetics, although variability does exist. It is hypothesized that this variability is due to the process that controls both the influx and efflux of creatine across the cell membrane, and is likely due to a decrease in activity of the creatine transporter from various compounding factors. Furthermore, additional data suggests that an individual's initial biological profile may partially determine the efficacy of a creatine supplementation protocol. This brief review will examine both animal and human research in relation to the regulation and expression of the creatine transporter (CreaT). The current literature is very preliminary in regards to examining how creatine supplementation affects CreaT expression while concomitantly following a resistance training regimen. In conclusion, it is prudent that future research begin to examine CreaT expression due to creatine supplementation in humans in much the same way as in animal models.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.