ArticleEndocrinology2008
Sexual differentiation of vasopressin innervation of the brain: cell death versus phenotypic differentiation.
Article in Endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- DNA methylation and demethylation shape sexual differentiation of neurochemical phenotype.Hormones and behavior · 2023Article
- Sex Differences in Acute Neuroendocrine Responses to Stressors in Rodents and Humans.Cold Spring Harbor perspectives in biology · 2022Article
- Birth delivery mode alters perinatal cell death in the mouse brain.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain.Nature reviews. Neuroscience · 2017Review
- Neonatal Inhibition of DNA Methylation Alters Cell Phenotype in Sexually Dimorphic Regions of the Mouse Brain.Endocrinology · 2017Article
- Cellular and molecular mechanisms of sexual differentiation in the mammalian nervous system.Frontiers in neuroendocrinology · 2016Review
- Epigenetics and sex differences in the brain: A genome-wide comparison of histone-3 lysine-4 trimethylation (H3K4me3) in male and female mice.Experimental neurology · 2015Review
- Cell death in the central division of the medial preoptic nucleus of male and female lamb fetuses.Brain research · 2014Article
- Sensitive periods for hormonal programming of the brain.Current topics in behavioral neurosciences · 2014Review
- Sex differences in circadian timing systems: implications for disease.Frontiers in neuroendocrinology · 2014Review
- Sexually dimorphic effects of a prenatal immune challenge on social play and vasopressin expression in juvenile rats.Biology of sex differences · 2012Article
- Neonatal MeCP2 is important for the organization of sex differences in vasopressin expression.Epigenetics · 2012Article
- Effects of blocking developmental cell death on sexually dimorphic calbindin cell groups in the preoptic area and bed nucleus of the stria terminalis.Biology of sex differences · 2012Article
- Effects of Bax gene deletion on social behaviors and neural response to olfactory cues in mice.The European journal of neuroscience · 2011Article
- Estradiol-dependent catecholaminergic innervation of auditory areas in a seasonally breeding songbird.The European journal of neuroscience · 2011Article
- Reframing sexual differentiation of the brain.Nature neuroscience · 2011Review
- Cell death and sexual differentiation of behavior: worms, flies, and mammals.Current opinion in neurobiology · 2010Review
- Sexual differentiation and development of forebrain reproductive circuits.Current opinion in neurobiology · 2010Review
- Control of cell number in the sexually dimorphic brain and spinal cord.Journal of neuroendocrinology · 2009Review
- Sex differences in NeuN- and androgen receptor-positive cells in the bed nucleus of the stria terminalis are due to Bax-dependent cell death.Neuroscience · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In most vertebrates studied, males have more vasopressin (VP) cells in the bed nucleus of the stria terminalis, or homologous vasotocin cells in nonmammalian species, than females. Previous research excluded differential cell birth and migration as likely mechanisms underlying this difference, leaving just differential cell death and phenotypic differentiation of existing cells. To differentiate between these remaining possibilities, we compared VP cell number in wild-type mice vs. mice overexpressing the anti-cell death factor, Bcl-2. All animals were gonadectomized in adulthood and given testosterone capsules. Three weeks later, brains were processed for in situ hybridization to identify VP cells. Bcl-2 overexpression increased VP cell number in both sexes but did not reduce the sex difference. We repeated this experiment in mice with a null mutation of the pro-cell death gene, Bax, and obtained similar results; cell number was increased in Bax(-/-) mice of both sexes, but males had about 40% more VP cells, regardless of Bax gene status. Taken together, cell death is unlikely to account for the sex difference in VP cell number, leaving differentiation of cell phenotype as the most likely underlying mechanism. We also used immunocytochemistry to examine VP projections in Bcl-2-overexpressing mice. As expected, males showed denser VP-immunoreactive fibers than females in the lateral septum, a projection area of the bed nucleus of the stria terminalis. However, even though Bcl-2 overexpression increased VP cell number, it did not affect fiber density. Thus, a compensatory mechanism may control total septal innervation regardless of the number of contributing cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.