ReviewCurrent opinion in cell biology2008
Cracking the coregulator codes.
Review in Current opinion in cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 76 citations in OpenAlex.
- Significant Association of Estrogen Receptor-β Isoforms and Coactivators in Breast Cancer Subtypes.Current issues in molecular biology · 2023Article
- ZMIZ proteins: partners in transcriptional regulation and risk factors for human disease.Journal of molecular medicine (Berlin, Germany) · 2022Review
- RNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Gene-Specific Actions of Transcriptional Coregulators Facilitate Physiological Plasticity: Evidence for a Physiological Coregulator Code.Trends in biochemical sciences · 2020Review
- Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans.PLoS genetics · 2019Article
- Estimating the Distribution of Protein Post-Translational Modification States by Mass Spectrometry.Journal of proteome research · 2018Article
- Steroids and the brain: 50years of research, conceptual shifts and the ascent of non-classical and membrane-initiated actions.Hormones and behavior · 2018Review
- Article
- Site selective reading of epigenetic markers by a dual-mode synthetic receptor array.Chemical science · 2017Article
- Liver X Receptor Agonist Modifies the DNA Methylation Profile of Synapse and Neurogenesis-Related Genes in the Triple Transgenic Mouse Model of Alzheimer's Disease.Journal of molecular neuroscience : MN · 2016Article
- The Mediator complex of Caenorhabditis elegans: insights into the developmental and physiological roles of a conserved transcriptional coregulator.Nucleic acids research · 2015Review
- Estrogen receptor coregulators and pioneer factors: the orchestrators of mammary gland cell fate and development.Frontiers in cell and developmental biology · 2014Review
- Article
- Identification of novel CDK9 and Cyclin T1-associated protein complexes (CCAPs) whose siRNA depletion enhances HIV-1 Tat function.Retrovirology · 2012Article
- Making a Short Story Long: Regulation of P-TEFb and HIV-1 Transcriptional Elongation in CD4+ T Lymphocytes and Macrophages.Biology · 2012Article
- Cullin 3 mediates SRC-3 ubiquitination and degradation to control the retinoic acid response.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Recovering protein-protein and domain-domain interactions from aggregation of IP-MS proteomics of coregulator complexes.PLoS computational biology · 2011Article
- Structural dynamics, intrinsic disorder, and allostery in nuclear receptors as transcription factors.The Journal of biological chemistry · 2011Review
- Corepressor effect on androgen receptor activity varies with the length of the CAG encoded polyglutamine repeat and is dependent on receptor/corepressor ratio in prostate cancer cells.Molecular and cellular endocrinology · 2011Article
- Genome-scale techniques highlight the epigenome and redefine fundamental principles of gene regulation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The study of the genetic code has collectively revealed that the biochemical basis of heredity is uniform for nearly all known forms of life. Genetic approaches have generated a much better appreciation and understanding of many aspects of biological processes-and in some cases provided strategies for the treatment of human diseases. Still, the enormous and undoubtedly impressive amount of information gathered on gene sequences, their myriad expression patterns and translation into proteins is insufficient to answer seemingly simpler questions such as to what sets us humans apart from much more undemanding species while sharing almost the same sets of genes. Regulation of the proteome by post-translational modifications (PTMs) is beginning to be understood as a major contributing factor to the structural and functional diversity in biology and for defining cellular mechanisms in particular. Covalent, PTMs provide an astonishingly rich and specific basis for an ultrafast regulation of cellular processes, many of which converge to transcription units to control gene expression. With this essay we intend to share with the reader the rapid growth of our knowledge of the many conjunctions that exist between PTMs and key cellular processes that have emerged by studying the nuclear receptors (NRs) and their transcriptional coregulators.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.