ArticlePhysiology & behavior2008
Gender differences in zebrafish responses to cocaine withdrawal.
Article in Physiology & behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 98 citations in OpenAlex.
- Tensor analysis of animal behavior by matricization and feature selection.Computers in biology and medicine · 2025Article
- Cocaine Differentially Affects Mitochondrial Function Depending on Exposure Time.International journal of molecular sciences · 2025Article
- Exploring the impact of acute solvent exposure on larval zebrafish behaviour.Frontiers in behavioral neuroscience · 2025Article
- β-Carboline (FG-7142) modulates fear but not anxiety-like behaviour in zebrafish.Scientific reports · 2024Article
- Influence of chronic administration of morphine and its withdrawal on the behaviour of zebrafish.Journal of biosciences · 2023Article
- The cognitive and behavioral effects of D-amphetamine and nicotine sensitization in adult zebrafish.Psychopharmacology · 2021Article
- Zebrafish as a Useful Tool in the Research of Natural Products With Potential Anxiolytic Effects.Frontiers in behavioral neuroscience · 2021Review
- Age Bias in Zebrafish Models of Epilepsy: What Can We Learn From Old Fish?Frontiers in cell and developmental biology · 2020Review
- Automated monitoring of behaviour in zebrafish after invasive procedures.Scientific reports · 2019Article
- Fluoxetine Exposure During Sexual Development Disrupts the Stress Axis and Results in Sex- and Time- Dependent Effects on the Exploratory Behavior in Adult ZebrafishFrontiers in neuroscience · 2019Article
- Adult zebrafish in CNS disease modeling: a tank that's half-full, not half-empty, and still filling.Lab animal · 2017Article
- Dopaminergic control of anxiety in young and aged zebrafish.Pharmacology, biochemistry, and behavior · 2017Article
- Zebrafish Get Connected: Investigating Neurotransmission Targets and Alterations in Chemical Toxicity.Toxics · 2016Article
- Neurobehavioural Changes and Brain Oxidative Stress Induced by Acute Exposure to GSM900 Mobile Phone Radiations in Zebrafish (Danio rerio).Toxicological research · 2016Article
- Rest mutant zebrafish swim erratically and display atypical spatial preferences.Behavioural brain research · 2015Article
- Prenatal and acute cocaine exposure affects neural responses and habituation to visual stimuli.Frontiers in neural circuits · 2015Article
- An integrative analysis of ethanol tolerance and withdrawal in zebrafish (Danio rerio).Behavioural brain research · 2015Article
- Sexual dimorphism in the hypophysiotropic tyrosine hydroxylase-positive neurons in the preoptic area of the teleost, Clarias batrachus.Biology of sex differences · 2015Article
- Recent advances with a novel model organism: alcohol tolerance and sensitization in zebrafish (Danio rerio).Progress in neuro-psychopharmacology & biological psychiatry · 2014Review
- Zebrafish models for translational neuroscience research: from tank to bedside.Trends in neurosciences · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The acute responses to cocaine and its withdrawal contribute to cocaine dependence and potentiate relapse, with gender being one of the genetic factors affecting the outcome. Here we report that in both male and female zebrafish (Danio rerio, AB strain), an initial low-dose cocaine treatment (1.5 muM, immersion) does not acutely change their behavior. The cocaine withdrawal, however, is associated with an anxiety-like state that develops earlier in female zebrafish but is more robust and persistent in males, and can be acutely attenuated by cocaine administration. This is not a result of gender differences in the expression of anxiety-like state, since behavioral responses to an anxiogenic drug, FG-7142, are similar in male and female zebrafish. The basal brain dopamine (DA) levels and the expression of dopamine transporter mRNA (zDAT) show no significant sexual dimorphism. Acute cocaine exposure does not significantly change DA or zDAT. Withdrawal from repeated cocaine administration results in an overall reduction in zDAT, as well as an increase in DA levels. Neither treatment leads to significant gender differences in brain DA or zDAT. The common and gender-specific effects of cocaine on zebrafish, a well-characterized model of vertebrate development and genetics, should help in understanding the mechanisms involved in the anxiety associated with cocaine withdrawal and provide new opportunities in search for therapeutic solutions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.