Evidence map›Paper›PMID 18499027›Full record

ReviewGastroenterology clinics of North America2008

Enteric autoantibodies and gut motility disorders.

Purna Kashyap, Gianrico Farrugia

Open access · greenAbstract readReview
In one paragraph

Review in Gastroenterology clinics of North America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Review
  4. Immunity, Ion Channels and Epilepsy.International journal of molecular sciences · 2022
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Anti-enteric neuronal antibodies and the irritable bowel syndrome.Journal of neurogastroenterology and motility · 2012
    Article
  15. Cellular pathogenesis of diabetic gastroenteropathy.Minerva gastroenterologica e dietologica · 2009
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Purna KashyapMayo Clinic, Rochester, MN 55905, USA.
Gianrico Farrugia
Mayo Clinic · USMayo Clinic in Arizona · US

Funding

Physiological Characterization and Data Integration CoreP01DK068055 · NIDDK · MAYO CLINIC ROCHESTER · PI ORDOG, TAMAS · 2004 to 2019
$23.8M
MECHANOTRANSDUCTION IN INTESTINAL SMOOTH MUSCLE CELLSR01DK052766 · NIDDK · MAYO CLINIC ROCHESTER · PI BEYDER, ARTHUR, FARRUGIA, GIANRICO · 1997 to 2025
$8.3M
CALCIUM DYNAMICS IN INTERSTITIAL CELLS OF CAJALR01DK057061 · NIDDK · MAYO CLINIC ROCHESTER · PI GIANRICO FARRUGIA, Tamas Ordog · 2000 to 2026
$8.2M
NIDDK NIH HHS DK52766NIDDK NIH HHS DK57061NIDDK NIH HHS P01 DK068055NIDDK NIH HHS P01 DK 68055NIDDK NIH HHS R01 DK052766NIDDK NIH HHS R01 DK057061
6 · The paper itself

Abstract

Increasing evidence suggests that a subset of gastrointestinal motility disorders is associated with the presence of circulating antibodies. These antibodies are directed against various molecular targets, the best known being anti-neuronal nuclear antibody (ANNA-1 or anti-Hu) associated with paraneoplastic motility disorders. There is also evidence that the presence of distinct autoantibody profiles is associated with non-paraneoplastic motility disorders. This review focuses on the types of antibodies associated with gastrointestinal motility disorders and the significance of these antibodies. Algorithms are suggested for the work-up and treatment of patients with circulating antibodies associated with gastrointestinal motility disorders.

Indexed as

AutoantibodiesGastrointestinal MotilityHumansIntestinal NeoplasmsParaneoplastic SyndromesAutoantibodies

Identifiers

PMID18499027
PMCPMC2448392
OpenAlexW2006800096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.