ArticleJournal of the American Chemical Society2008
Liquid crystalline phase of G-tetrad DNA for NMR study of detergent-solubilized proteins.
Article in Journal of the American Chemical Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
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- Extending the applicability of P3D for structure determination of small molecules.Magnetic resonance (Gottingen, Germany) · 2021Article
- Partial alignment, residual dipolar couplings and molecular symmetry in solution NMR.Journal of biomolecular NMR · 2019Article
- Solution structure of yeast Rpn9: insights into proteasome lid assembly.The Journal of biological chemistry · 2015Article
- Familial Alzheimer's mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site.Nature communications · 2014Article
- Structural basis for TatA oligomerization: an NMR study of Escherichia coli TatA dimeric structure.PloS one · 2014Article
- Partial alignment and measurement of residual dipolar couplings of proteins under high hydrostatic pressure.Journal of biomolecular NMR · 2013Article
- Modulating alignment of membrane proteins in liquid-crystalline and oriented gel media by changing the size and charge of phospholipid bicelles.Journal of biomolecular NMR · 2013Article
- DNA nanotubes for NMR structure determination of membrane proteins.Nature protocols · 2013Article
- When detergent meets bilayer: birth and coming of age of lipid bicelles.Progress in nuclear magnetic resonance spectroscopy · 2013Review
- Construction of covalent membrane protein complexes and high-throughput selection of membrane mimics.Journal of the American Chemical Society · 2012Article
- NMR as a unique tool in assessment and complex determination of weak protein-protein interactions.Topics in current chemistry · 2012Review
- The use of residual dipolar coupling in studying proteins by NMR.Topics in current chemistry · 2012Review
- pK(a) coupling at the intein active site: implications for the coordination mechanism of protein splicing with a conserved aspartate.Journal of the American Chemical Society · 2011Article
- Paramagnetic-based NMR restraints lift residual dipolar coupling degeneracy in multidomain detergent-solubilized membrane proteins.Journal of the American Chemical Society · 2011Article
- Protein alignment using cellulose nanocrystals: practical considerations and range of application.Journal of biomolecular NMR · 2010Article
- A combinatorial NMR and EPR approach for evaluating the structural ensemble of partially folded proteins.Journal of the American Chemical Society · 2010Article
- The complete influenza hemagglutinin fusion domain adopts a tight helical hairpin arrangement at the lipid:water interface.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Solution structure and functional analysis of the influenza B proton channel.Nature structural & molecular biology · 2009Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The liquid crystalline phase consisting of the potassium salt of the dinucleotide d(GpG) is compatible with detergents commonly used for solubilizing membrane proteins, including dodecylphosphocholine, the lysolipid 1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine, and small bicelles consisting of dihexanoyl phosphatidylcholine and dimyristoyl phosphatidylcholine. The chiral nematic liquid crystalline phase of d(GpG) consists of long columns of stacked G-tetrad structures and carry a net negative charge. For water-soluble systems, the protein alignment induced by d(GpG) is very similar to that observed for liquid crystalline Pf1 bacteriophage, but of opposite sign. Alignment of the detergent-solubilized fusion domain of hemagglutinin is demonstrated to be homogeneous and stable, resulting in high quality NMR spectra suitable for the measurement of residual dipolar couplings.
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