ArticleTrends in analytical chemistry : TRAC2008
Extending the breadth of metabolite profiling by gas chromatography coupled to mass spectrometry.
Article in Trends in analytical chemistry : TRAC, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed.
- Metabolomics and transcriptomics identify pathway differences between visceral and subcutaneous adipose tissue in colorectal cancer patients: the ColoCare study.The American journal of clinical nutrition · 2015Trial
- Metabolic reprogramming in plant defense: linking signaling networks to metabolomics-driven insights.Plant signaling & behavior · 2026Review
- Compost and rootstock effects on fibrous root physiology and bacterial community composition in young citrus trees under endemic Huanglongbing.Scientific reports · 2026Article
- Cattle type and liver abscess occurrence impact aged beef steak instrumental retail color and metabolomics.Journal of animal science · 2026Article
- Dissecting inflammation in the immunemetabolomic era.Cellular and molecular life sciences : CMLS · 2025Review
- Nitrogen-fixing symbiosis induces differential accumulation ofFrontiers in plant science · 2025Article
- Advancements in breath-based diagnostics for pancreatic cancer: Current insights and future perspectives.World journal of gastrointestinal oncology · 2024Article
- Diagnosis of Carcinogenic Pathologies through Breath Biomarkers: Present and Future Trends.Biomedicines · 2023Review
- Quantum Chemical Prediction of Electron Ionization Mass Spectra of Trimethylsilylated Metabolites.Analytical chemistry · 2022Article
- Multi-Omics Approaches Unravel Specific Features of Embryo and Endosperm in Rice Seed Germination.Frontiers in plant science · 2022Article
- Automated Trimethyl Sulfonium Hydroxide Derivatization Method for High-Throughput Fatty Acid Profiling by Gas Chromatography-Mass Spectrometry.Molecules (Basel, Switzerland) · 2021Article
- A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice.eLife · 2021Article
- A Metabolomics Workflow for Analyzing Complex Biological Samples Using a Combined Method of Untargeted and Target-List Based Approaches.Metabolites · 2020Article
- Untargeted Metabolomic Analysis Combined With Multivariate Statistics Reveal Distinct Metabolic Changes in GPR40 Agonist-Treated Animals Related to Bile Acid Metabolism.Frontiers in molecular biosciences · 2020Article
- TDCIPP exposure affects Artemia franciscana growth and osmoregulation.The Science of the total environment · 2019Article
- Characterization and analysis of estrogenic cyclic phenone metabolites produced in vitro by rainbow trout liver slices using GC-MS, LC-MS and LC-TOF-MS.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2019Article
- A metabolic investigation of anticancer effect of G. glabra root extract on nasopharyngeal carcinoma cell line, C666-1.Molecular biology reports · 2019Article
- Challenges in Identifying the Dark Molecules of Life.Annual review of analytical chemistry (Palo Alto, Calif.) · 2019Review
- Adipose depot-specific effects of ileal interposition surgery in UCD-T2D rats: unexpected implications for obesity and diabetes.The Biochemical journal · 2018Article
- Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics.Nature methods · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Gas chromatography coupled to mass spectrometry (GC-MS) is one of the most frequently used tools for profiling primary metabolites. Instruments are mature enough to run large sequences of samples; novel advancements increase the breadth of compounds that can be analyzed, and improved algorithms and databases are employed to capture and utilize biologically relevant information. Around half the published reports on metabolite profiling by GC-MS focus on biological problems rather than on methodological advances. Applications span from comprehensive analysis of volatiles to assessment of metabolic fluxes for bioengineering. Method improvements emphasize extraction procedures, evaluations of quality control of GC-MS in comparison to other techniques and approaches to data processing. Two major challenges remain: rapid annotation of unknown peaks; and, integration of biological background knowledge aiding data interpretation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.