ArticleThe Journal of clinical investigation2008
Overindulgence and metabolic syndrome: is FoxO1 a missing link?
Article in The Journal of clinical investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Mitochondrial Transfer by Human Mesenchymal Stromal Cells Ameliorates Hepatocyte Lipid Load in a Mouse Model of NASH.Biomedicines · 2020Article
- Obesity genetics and cardiometabolic health: Potential for risk prediction.Diabetes, obesity & metabolism · 2019Review
- Lipidomic and transcriptomic analysis of western diet-induced nonalcoholic steatohepatitis (NASH) in female Ldlr -/- mice.PloS one · 2019Article
- Androgen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitis.Endocrine-related cancer · 2014Review
- Insulin-dependent apolipoprotein B degradation is mediated by autophagy and involves class I and class III phosphatidylinositide 3-kinases.Biochemical and biophysical research communications · 2013Article
- Hepatic ABCA1 and VLDL triglyceride production.Biochimica et biophysica acta · 2012Review
- Article
- Effects of insulin resistance and hepatic lipid accumulation on hepatic mRNA expression levels of apoB, MTP and L-FABP in non-alcoholic fatty liver disease.Experimental and therapeutic medicine · 2011Article
- Acute suppression of apo B secretion by insulin occurs independently of MTP.Biochemical and biophysical research communications · 2011Article
- Interleukin-6 mediates hepatic hypersecretion of apolipoprotein B.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- FoxO1 links hepatic insulin action to endoplasmic reticulum stress.Endocrinology · 2010Article
- Old and rising stars in the lymphoid liver.Seminars in immunopathology · 2009Article
- FoxO1 and hepatic lipid metabolism.Current opinion in lipidology · 2009Article
- The ever-expanding role of degradation in the regulation of apolipoprotein B metabolism.Journal of lipid research · 2009Review
- Article
- FoxO1 integrates insulin signaling to VLDL production.Cell cycle (Georgetown, Tex.) · 2008Review
- The many intersecting pathways underlying apolipoprotein B secretion and degradation.Trends in endocrinology and metabolism: TEM · 2008Review
- Genetic determinants of cardiometabolic risk: a proposed model for phenotype association and interaction.Journal of clinical lipidologyReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excessive production of triglyceride-rich VLDL, which can result from dietary overindulgence, underlies metabolic syndrome--a combination of disorders including high blood pressure, obesity, high triglyceride, and insulin resistance--and places individuals at increased risk of developing cardiovascular disease and type 2 diabetes. However, the link between VLDL overproduction and insulin resistance has remained unclear. VLDL assembly in the liver is catalyzed by microsomal triglyceride transfer protein (MTP). In this issue of the JCI, Kamagate et al. investigate the events controlling hepatic MTP expression and VLDL production and secretion (see the related article beginning on page 2347). They demonstrate that MTP is a target of the transcription factor FoxO1 and that excessive VLDL production associated with insulin resistance is caused by the inability of insulin to regulate FoxO1 transcriptional activation of MTP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.