ReviewClinical reviews in allergy & immunology2009
Pathogenesis and clinical significance of liver injury in celiac disease.
Review in Clinical reviews in allergy & immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- ESPEN guideline on clinical nutrition in liver disease.Clinical nutrition (Edinburgh, Scotland) · 2019Guideline
- Recurrent Projectile Vomiting as the Sole Presenting Feature of Coeliac Disease With Marsh-Oberhuber Grade 3C Enteropathy in a 13-Year-Old Girl: A Case Report.Clinical case reports · 2026Article
- Gluten's silent strike: Unmasking its impact on liver health.World journal of gastrointestinal pathophysiology · 2025Review
- A machine learning tool for early identification of celiac disease autoimmunity.Scientific reports · 2024Article
- Celiac Disease, Gluten-Free Diet and Metabolic Dysfunction-Associated Steatotic Liver Disease.Nutrients · 2024Review
- The Gut-Vascular Barrier as a New Protagonist in Intestinal and Extraintestinal Diseases.International journal of molecular sciences · 2023Review
- Review
- Elevated liver enzymes of newly diagnosed pediatric celiac patients-a prospective-observational study.European journal of pediatrics · 2022Observational
- Liver function changes following the introduction of a gluten-free diet in patients with celiac disease.Clinical and experimental hepatology · 2021Article
- Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation.World journal of gastroenterology · 2019Review
- Gluten-Induced Extra-Intestinal Manifestations in Potential Celiac Disease-Celiac Trait.Nutrients · 2019Review
- Celiac disease: From pathophysiology to treatment.World journal of gastrointestinal pathophysiology · 2017Review
- Diagnosis and Management of Autoimmune Hepatitis: Current Status and Future Directions.Gut and liver · 2016Review
- Liver involvement in pediatric celiac disease.World journal of gastroenterology · 2015Review
- Hepatic hemangioma in celiac patients: data from a large consecutive series.Gastroenterology research and practice · 2015Article
- Celiac disease and autoimmunity: review and controversies.Current allergy and asthma reports · 2013Review
- The effects of gluten-free diet on hypertransaminasemia in patients with celiac disease.International journal of preventive medicine · 2013Article
- Article
- Celiac disease markers in patients with liver diseases: a single center large scale screening study.World journal of gastroenterology · 2012Article
- Microscopic Enteritis; clinical features and correlations with symptoms.Gastroenterology and hepatology from bed to bench · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormalities of liver function are one of the manifold extraintestinal manifestations of celiac disease. Although the spectrum of liver manifestations associated with celiac disease is particularly wide, two main forms of liver damage namely, cryptogenic and autoimmune, appear to be strictly related to gluten-sensitive enteropathy. The most frequent finding is represented by a cryptogenic hypertransaminasemia, observed in about a half of untreated celiac patients, as an expression of a mild liver dysfunction with a histological picture of nonspecific reactive hepatitis (celiac hepatitis) reverting to normal after 6-12 months of a strict gluten-free diet. In a few cases, when celiac disease is diagnosed, a more severe liver injury, characterized by a cryptogenic chronic hepatitis or liver cirrhosis, is present. In these patients, liver damage can still improve after a gluten-free diet institution. Moreover, a close association between celiac disease and autoimmune liver disorders has been widely demonstrated. Indeed, celiac disease has been found in 3-7% of patients with primary biliary cirrhosis, in 3-6% with autoimmune hepatitis, and in 2-3% with primary sclerosing cholangitis. Differently from cryptogenic liver injury, autoimmune liver dysfunction, found in celiac disease, does not usually improve after a gluten-free diet. Presently, it is difficult to establish if the two main kinds of liver injury found in celiac disease (cryptogenic and autoimmune) are discrete entities with a different pathogenesis or if they are an expression of the same disorder where genetic factors and the duration of gluten exposure may determine the severity and the pattern of liver injury.
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