ArticleRheumatology international2008
The relationship between serum trace element levels and clinical parameters in patients with fibromyalgia.
Article in Rheumatology international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07519824 (The Role of Bioelements in Fibromyalgia), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Bioelements in Fibromyalgia: Disease Activity or Depression-Anxiety?
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Multi-ancestry meta-analysis of genome-wide association studies discovers 67 new loci associated with chronic back pain.Nature communications · 2025Pooled it
- Vitamin and mineral status in chronic fatigue syndrome and fibromyalgia syndrome: A systematic review and meta-analysis.PloS one · 2017Pooled it
- Is balneotherapy effective for fibromyalgia? Results from a 6-month double-blind randomized clinical trial.Clinical rheumatology · 2018Trial
- Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia?Rheumatology international · 2013Trial
- Intravenous micronutrient therapy (Myers' Cocktail) for fibromyalgia: a placebo-controlled pilot study.Journal of alternative and complementary medicine (New York, N.Y.) · 2009Trial
- Evolving Concepts in the Diagnosis and Management of Fibromyalgia: A Moving Target.Journal of pain research · 2026Review
- The Relationship Between Lipid Peroxidation, Serum Antioxidant Vitamin, Inflammatory Biomarker, Trace Elements, and Macro-Minerals With Bangladeshi Fibromyalgia Patients: A Case-Control Study.Health science reports · 2025Article
- Reevaluating fibromyalgia diagnosis: a proposal to integrate deep tendon reflex responses into current criteria.Rheumatology international · 2025Review
- Effects of Antioxidants on Pain Perception in Patients with Fibromyalgia-A Systematic Review.Journal of clinical medicine · 2022Review
- The position of geochemical variables as causal co-factors of diseases of unknown aetiology.SN applied sciences · 2022Review
- Oxidative Stress in Fibromyalgia: From Pathology to Treatment.Oxidative medicine and cellular longevity · 2022Review
- Re-Examining Myofascial Pain Syndrome: Toward Biomarker Development and Mechanism-Based Diagnostic Criteria.Current rheumatology reports · 2021Review
- Magnesium in Aging, Health and Diseases.Nutrients · 2021Review
- Magnesium and Pain.Nutrients · 2020Review
- The Role of Magnesium in Neurological Disorders.Nutrients · 2018Review
- Involvement of TRPM2 and TRPV1 channels on hyperalgesia, apoptosis and oxidative stress in rat fibromyalgia model: Protective role of selenium.Scientific reports · 2017Article
- QT dispersion and P wave dispersion in patients with fibromyalgia.European journal of rheumatology · 2016Article
- Selenium and Zinc Status in Chronic Myofascial Pain: Serum and Erythrocyte Concentrations and Food Intake.PloS one · 2016Article
- Redox and trace metal regulation of ion channels in the pain pathway.The Biochemical journal · 2015Review
- A quest for better understanding of biochemical changes in fibromyalgia syndrome.Indian journal of clinical biochemistry : IJCB · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the association between serum trace elements and clinical findings such as number of sensitive tender points, severity of fatigue and functional status in patients with fibromyalgia (FM). Thirty-two patients diagnosed as having FM according to the ACR 1990 criteria and 32 normal healthy controls (NHC) were included in this study. The demographic data, disease duration, number of tender points and accompanying symptoms (fatigue, sleep disorders, headache, paresthesia, irritable bowel syndrome, sicca symptoms, Raynaud's phenomena) of the patients were noted. Visual analog scale (10 cm) was implemented to estimate daily severity of pain and fatigue. Fibromyalgia impact questionnaire was used for functional assessment. Serum selenium (microg/dL) and serum zinc (microg/dL) levels were measured by atomic absorption spectrometer. Serum magnesium (mmol/L) level was measured by the original kits of Abbott Aeroset auto-analyzer. The mean age of patients in FM group and NHC were calculated as 42.9 (SD = 7.7) years and 41.3 (SD = 9.7) years, respectively. Serum levels of zinc (P = 0.001) and magnesium (P = 0.002) were significantly decreased by FM groups, whereas there was no considerable difference with selenium levels of both groups (P > 0.05). Association between serum zinc level and number of tender points (P = 0.008) and that between fatigue and magnesium level (P = 0.003) was found as meaningful. According to the results of this study, it was asserted that serum magnesium and zinc levels may play an important role in the pathophysiology of FM.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.