Evidence map›Paper›PMID 18495944›Full record

ReviewThe Journal of endocrinology2008

Back to the future: a new look at 'old' vitamin D.

Rene F Chun, John S Adams, Martin Hewison

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 85 citations in OpenAlex.

  1. Vitamin D Deficiency and Survival in Children after Hematopoietic Stem Cell Transplant.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2015
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  20. Vitamin d and cardiovascular disease.Current treatment options in cardiovascular medicine · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rene F ChunDepartment of Orthopaedic Surgery, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA.
John S Adams
Martin Hewison
University of California, Los Angeles · US

Funding

VITAMIN D RESISTANCE: MONKEY TO MANR01AR037399 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ADAMS, JOHN S · 1988 to 2013
$4.3M
Vitamin D and Barrier FunctionR01AR050626 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HEWISON, MARTIN · 2004 to 2008
$1.4M
NIAMS NIH HHS R01 AR037399NIAMS NIH HHS R01 AR050626
6 · The paper itself

Abstract

Our perception of the vitamin D system continues to evolve. Recent studies have re-evaluated the parameters for adequate vitamin D status in humans, revealing a high prevalence of insufficiency in many populations throughout the world. Other reports have highlighted the potential consequences of vitamin D insufficiency beyond established effects on bone homeostasis. Most notably, there is now strong evidence of a role for vitamin D in modulating innate and adaptive immunities, with insufficiency being linked to infectious disease and other immune disorders. To date, signaling pathways for these new responses to vitamin D have been based on established endocrine models for active 1,25-dihydroxyvitamin D, despite present evidence for more localized, intracrine modes of action. In the following review, we provide a fresh perspective on vitamin D signaling in non-classical target cells such as macrophages by highlighting novel factors associated with the transport and action of this pluripotent secosteroid.

Indexed as

AnimalsHumansImmunity, InnateMacrophagesSignal TransductionVitamin DVitamin D DeficiencyVitamin D

Identifiers

PMID18495944
PMCPMC2699326
OpenAlexW2144352861

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.