ArticleRNA (New York, N.Y.)2008
In vitro expression of the HIV-2 genomic RNA is controlled by three distinct internal ribosome entry segments that are regulated by the HIV protease and the Gag polyprotein.
Article in RNA (New York, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression.Nature communications · 2025Article
- Identification of cryptic putative IRESs within the ORF encoding the nonstructural proteins of the human rhinovirus 16 genome.Archives of virology · 2021Article
- Two ribosome recruitment sites direct multiple translation events within HIV1 Gag open reading frame.Nucleic acids research · 2017Article
- A researcher's guide to the galaxy of IRESs.Cellular and molecular life sciences : CMLS · 2017Review
- Translational Control of the HIV Unspliced Genomic RNA.Viruses · 2015Review
- HIV-2 genomic RNA accumulates in stress granules in the absence of active translation.Nucleic acids research · 2014Article
- Functional mechanisms of the cellular prion protein (PrP(C)) associated anti-HIV-1 properties.Cellular and molecular life sciences : CMLS · 2012Article
- Different effects of the TAR structure on HIV-1 and HIV-2 genomic RNA translation.Nucleic acids research · 2012Article
- Viral SELEX reveals individual and cooperative roles of the C-box and G-box in HIV-2 replication.RNA (New York, N.Y.) · 2011Article
- Activation of a microRNA response in trans reveals a new role for poly(A) in translational repression.Nucleic acids research · 2011Article
- A conserved structure within the HIV gag open reading frame that controls translation initiation directly recruits the 40S subunit and eIF3.Nucleic acids research · 2011Article
- A new type of IRES within gag coding region recruits three initiation complexes on HIV-2 genomic RNA.Nucleic acids research · 2010Article
- HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage.PloS one · 2009Article
- A 5'UTR-spliced mRNA isoform is specialized for enhanced HIV-2 gag translation.Journal of molecular biology · 2009Article
- Toward a structural understanding of IRES RNA function.Current opinion in structural biology · 2009Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
The HIV-2 genomic RNA serves both as a messenger for protein synthesis and as a genome for viral assembly and particle production. Our previous work has shown that the HIV-2 genomic RNA encodes two additional Gag proteins that are N-terminal truncated isoforms of the p57 Gag polyprotein. In this study, by the use of mono- and bicistronic RNAs we show that translation at the three AUGs is driven by three distinct and independent internal ribosome entry segments both in vitro and ex vivo. Furthermore we used the recombinant Gag and HIV-2 protease to show that, in vitro, translation is tightly regulated by these two viral proteins. This regulation is exerted both at the level of protein production and also on the selection of the AUG initiation site which changes the ratio at which the three different Gag isoforms are produced.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.