ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Postsynaptic action of brain-derived neurotrophic factor attenuates alpha7 nicotinic acetylcholine receptor-mediated responses in hippocampal interneurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Dipyridamole monotherapy in schizophrenia: pilot of a novel treatment approach by modulation of purinergic signaling.Psychopharmacology · 2011Trial
- Autologous cord blood in children with cerebral palsy: a review.International journal of molecular sciences · 2019Review
- From Cannabinoids and Neurosteroids to Statins and the Ketogenic Diet: New Therapeutic Avenues in Rett Syndrome?Frontiers in neuroscience · 2019Review
- Adenosine ABritish journal of pharmacology · 2018Article
- Promoter IV-BDNF deficiency disturbs cholinergic gene expression of CHRNA5, CHRM2, and CHRM5: effects of drug and environmental treatments.Journal of neurochemistry · 2017Article
- Clinical and Environmental Correlates of Serum BDNF: A Descriptive Study with Plausible Implications for AD Research.Current Alzheimer research · 2017Article
- BDNF-induced presynaptic facilitation of GABAergic transmission in the hippocampus of young adults is dependent of TrkB and adenosine A2A receptors.Purinergic signalling · 2016Article
- Brain derived neurotrophic factor keeps pattern electroretinogram from dropping after superior colliculus lesion in mice.International journal of ophthalmology · 2016Article
- Adenosine A2A receptor activation is determinant for BDNF actions upon GABA and glutamate release from rat hippocampal synaptosomes.Purinergic signalling · 2015Article
- The DYX2 locus and neurochemical signaling genes contribute to speech sound disorder and related neurocognitive domains.Genes, brain, and behavior · 2015Article
- Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- T-cell receptor activation decreases excitability of cortical interneurons by inhibiting α7 nicotinic receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Nerve growth factor in the hippocamposeptal system: evidence for activity-dependent anterograde delivery and modulation of synaptic activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Tuning and fine-tuning of synapses with adenosine.Current neuropharmacology · 2009Article
- Triggering neurotrophic factor actions through adenosine A2A receptor activation: implications for neuroprotection.British journal of pharmacology · 2009Review
- GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A receptors.Journal of neurochemistry · 2009Article
- Trophic factor-induced intracellular calcium oscillations are required for the expression of postsynaptic acetylcholine receptors during synapse formation between Lymnaea neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nicotinic mechanisms acting on the hippocampus influence attention, learning, and memory and constitute a significant therapeutic target for many neurodegenerative, neurological, and psychiatric disorders. Here, we report that brain-derived neurotrophic factor (BDNF) (1-100 ng/ml), a member of the neurotrophin gene family, rapidly decreases alpha7 nicotinic acetylcholine receptor responses in interneurons of the hippocampal CA1 stratum radiatum. Such effect is dependent on the activation of the TrkB receptor and involves the actin cytoskeleton; noteworthy, it is compromised when the extracellular levels of the endogenous neuromodulator adenosine are reduced with adenosine deaminase (1 U/ml) or when adenosine A(2A) receptors are blocked with SCH 58261 (2-(2-furanyl)-7-(2-phenylethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine) (100 nm). The intracellular application of U73122 (1-[6[[(17beta)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione) (5 mum), a broad-spectrum inhibitor of phospholipase C, or GF 109203X (bisindolylmaleimide I) (2 mum), a general inhibitor of protein kinase C isoforms, blocks BDNF-induced inhibition of alpha7 nicotinic acetylcholine receptor function. Moreover, in conditions of simultaneous intracellular dialysis of the fast Ca(2+) chelator BAPTA (10 mm) and removal of extracellular Ca(2+) ions, the inhibitory action of BDNF is further prevented. The present findings disclose a novel target for rapid actions of BDNF that might play important roles on synaptic transmission and plasticity in the brain.
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