ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Action-based body maps in the spinal cord emerge from a transitory floating organization.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Neurorehabilitation in the 21st Century: New Science, New Strategies, New Expectations.Neurorehabilitation and neural repair · 2026Review
- Teneurin-3 and latrophilin-2 are required for somatotopic map development and somatosensory topognosis.Current biology : CB · 2026Article
- Expression and localization of NMDA receptor GluN2 subunits in dorsal horn pain circuits across sex, species, and late postnatal development.bioRxiv : the preprint server for biology · 2025Article
- The mechanotransduction protein STOML3 is required for proprioceptor plasticity following peripheral nerve regeneration.Experimental physiology · 2025Article
- Teneurin-3 and latrophilin-2 are required for somatotopic map formation and somatosensory topognosis.bioRxiv : the preprint server for biology · 2025Article
- Making brain-computer interfaces as reliable as muscles.Journal of neural engineering · 2025Review
- Cortical reorganization following dorsal spinal injuries in newborn monkeys reveals a critical period in the development of the somatosensory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Microglial Refinement of A-Fiber Projections in the Postnatal Spinal Cord Dorsal Horn Is Required for Normal Maturation of Dynamic Touch.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Updating perspectives on spinal cord function: motor coordination, timing, relational processing, and memory below the brain.Frontiers in systems neuroscience · 2024Review
- The Bcm rule allows a spinal cord model to learn rhythmic movements.Biological cybernetics · 2023Article
- Sleep, plasticity, and sensory neurodevelopment.Neuron · 2022Review
- Heksor: the central nervous system substrate of an adaptive behaviour.The Journal of physiology · 2022Article
- Prenatal development of neonatal vocalizations.eLife · 2022Article
- The development of descending serotonergic modulation of the spinal nociceptive network: a life span perspective.Pediatric research · 2022Review
- Diversified physiological sensory input connectivity questions the existence of distinct classes of spinal interneurons.iScience · 2022Article
- Discrete field potentials produced by coherent activation of spinal dorsal horn neurons.Experimental brain research · 2022Article
- Selective Targeting of Serotonin 5-HT1a and 5-HT3 Receptors Attenuates Acute and Long-Term Hypersensitivity Associated With Neonatal Procedural Pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Review
- Altered sensory innervation and pain hypersensitivity in a model of young painful arthritic joints: short- and long-term effects.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Article
- Changes in Sensorimotor Connectivity to dI3 Interneurons in Relation to the Postnatal Maturation of Grasping.Frontiers in neural circuits · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During development primary afferents grow into and establish neuronal connections in the spinal cord, thereby forming the basis for how we perceive sensory information and control our movements. In the somatosensory system, myriads of primary afferents, conveying information from different body locations and sensory modalities, get organized in the dorsal horn of the spinal cord so that spinal multisensory circuits receive topographically ordered information. How this intricate pathfinding is brought about during development is, however, largely unknown. Here we show that a body representation closely related to motor patterns emerges from a transitory floating and plastic organization through profound activity-dependent rewiring, involving both sprouting and elimination of afferent connections, and provide evidence for cross-modality interactions in the alignment of the multisensory input. Thus, far from being inborn and stereotypic, the dorsal horn of the spinal cord now appears to be a highly adaptive brain-body interface.
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