ArticleJournal of clinical microbiology2008
Are variable-number tandem repeats appropriate for genotyping Mycobacterium leprae?
Article in Journal of clinical microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 38 citations in OpenAlex.
- Genotyping ofIranian journal of microbiology · 2023Article
- Capsules, toxins and AtxA as virulence factors of emerging Bacillus cereus biovar anthracis.PLoS neglected tropical diseases · 2015Article
- Drug and multidrug resistance among Mycobacterium leprae isolates from Brazilian relapsed leprosy patients.Journal of clinical microbiology · 2012Article
- Genotyping of Mycobacterium leprae from Brazilian leprosy patients suggests the occurrence of reinfection or of bacterial population shift during disease relapse.Journal of medical microbiology · 2011Article
- DNA fingerprinting of Mycobacterium leprae strains using variable number tandem repeat (VNTR) - fragment length analysis (FLA).Journal of visualized experiments : JoVE · 2011Article
- Transmission of leprosy in Qiubei County, Yunnan, China: insights from an 8-year molecular epidemiology investigation.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2011Article
- Mycobacterium leprae-host-cell interactions and genetic determinants in leprosy: an overview.Future microbiology · 2011Review
- Mycobacterium leprae: genes, pseudogenes and genetic diversity.Future microbiology · 2011Review
- Comparative genomic and phylogeographic analysis of Mycobacterium leprae.Nature genetics · 2009Article
- Population-based molecular epidemiology of leprosy in Cebu, Philippines.Journal of clinical microbiology · 2009Article
- Rapid variable-number tandem-repeat genotyping for Mycobacterium leprae clinical specimens.Journal of clinical microbiology · 2009Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
Comparative genomics analysis of the Tamil Nadu strain of Mycobacterium leprae has uncovered several polymorphic sites with potential as epidemiological tools. In this study we compared the stability of two different markers of genomic biodiversity of M. leprae in several biopsy samples isolated from the same leprosy patient. The first type comprises five different variable-number tandem repeats (VNTR), while the second is composed of three single nucleotide polymorphisms (SNP). Contrasting results were obtained, since no variation was seen in the SNP profiles of M. leprae from 42 patients from 7 different locations in Mali whereas the VNTR profiles varied considerably. Furthermore, since variation in the VNTR pattern was seen not only between different isolates of M. leprae but also between biopsy samples from the same patient, these VNTR may be too dynamic for use as epidemiological markers for leprosy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.