ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2008
Long-term fasting decreases mitochondrial avian UCP-mediated oxygen consumption in hypometabolic king penguins.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Low resting metabolic rate and increased hunger due to β-MSH and β-endorphin deletion in a canine model.Science advances · 2024Article
- HyperpolarizedMagnetic resonance in medicine · 2022Article
- Article
- Oxidative stress and mitochondrial responses to stress exposure suggest that king penguins are naturally equipped to resist stress.Scientific reports · 2019Article
- Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost.Functional ecology · 2018Article
- Lipid-induced thermogenesis is up-regulated by the first cold-water immersions in juvenile penguins.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- Variation in the link between oxygen consumption and ATP production, and its relevance for animal performance.Proceedings. Biological sciences · 2015Review
- Article
- Selective upregulation of lipid metabolism in skeletal muscle of foraging juvenile king penguins: an integrative study.Proceedings. Biological sciences · 2012Article
- Up-regulation of avian uncoupling protein in cold-acclimated and hyperthyroid ducklings prevents reactive oxygen species production by skeletal muscle mitochondria.BMC physiology · 2010Article
- Oxygen recovery up-regulates avian UCP and ANT in newly hatched ducklings.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2010Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In endotherms, regulation of the degree of mitochondrial coupling affects cell metabolic efficiency. Thus it may be a key contributor to minimizing metabolic rate during long periods of fasting. The aim of the present study was to investigate whether variation in mitochondrial avian uncoupling proteins (avUCP), as putative regulators of mitochondrial oxidative phosphorylation, may contribute to the ability of king penguins (Aptenodytes patagonicus) to withstand fasting for several weeks. After 20 days of fasting, king penguins showed a reduced rate of whole animal oxygen consumption (Vo2; -33%) at rest, together with a reduced abundance of avUCP and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC1-alpha) mRNA in pectoralis muscle (-54%, -36%, respectively). These parameters were restored after the birds had been refed for 3 days. Furthermore, in recently fed, but not in fasted penguins, isolated muscle mitochondria showed a guanosine diphosphate-inhibited, fatty acid plus superoxide-activated respiration, indicating the presence of a functional UCP. It was calculated that variation in mitochondrial UCP-dependent respiration in vitro may contribute to nearly 20% of the difference in resting Vo2 between fed or refed penguins and fasted penguins measured in vivo. These results suggest that the lowering of avUCP activity during periods of long-term energetic restriction may contribute to the reduction in metabolic rate and hence the ability of king penguins to face prolonged periods of fasting.
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