ArticleAmerican journal of physiology. Renal physiology2008
Potassium channel contributions to afferent arteriolar tone in normal and diabetic rat kidney.
Article in American journal of physiology. Renal physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Aging Alters Hair Cell Physiological Properties in Mice With Late-Onset Age-Related Hearing Loss.Aging cell · 2026Article
- Potassium channels in vascular smooth muscle cells.Physiological reviews · 2026Review
- Mesoporous silica and alumina nanoparticles to improve drug delivery of pioglitazone on diabetic type 1 nephropathy in rats.Research in pharmaceutical sciences · 2024Article
- The key mediator of diabetic kidney disease: Potassium channel dysfunction.Genes & diseases · 2024Review
- The renal vasodilatation from β-adrenergic activation in vivo in rats is not driven by KExperimental physiology · 2024Article
- Impact of aging on vascular ion channels: perspectives and knowledge gaps across major organ systems.American journal of physiology. Heart and circulatory physiology · 2023Review
- Oxidation Driven Reversal of PIPFunction (Oxford, England) · 2023Article
- Ion channels and transporters in diabetic kidney disease.Current topics in membranes · 2019Review
- Inactivation of p66Shc Decreases Afferent Arteriolar KDiabetes · 2018Article
- Diabetes modifies the role of prostanoids and potassium channels which regulate the hypereactivity of the rabbit renal artery to BNP.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
- Article
- Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth.Advances in pharmacology (San Diego, Calif.) · 2017Review
- Store-operated calcium entry and diabetic complications.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Renal autoregulation in health and disease.Physiological reviews · 2015Review
- Enhanced large conductance K+ channel activity contributes to the impaired myogenic response in the cerebral vasculature of Fawn Hooded Hypertensive rats.American journal of physiology. Heart and circulatory physiology · 2014Article
- Tempol prevents altered K(+) channel regulation of afferent arteriolar tone in diabetic rat kidney.Hypertension (Dallas, Tex. : 1979) · 2012Article
- Renal protection of in vivo administration of tempol in streptozotocin-induced diabetic rats.Journal of pharmacological sciences · 2012Article
- Closure of multiple types of K+ channels is necessary to induce changes in renal vascular resistance in vivo in rats.Pflugers Archiv : European journal of physiology · 2011Article
- Pathophysiology of the diabetic kidney.Comprehensive Physiology · 2011Review
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4 authors at 2 institutions in 2 countries.
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Abstract
We previously reported an enhanced tonic dilator impact of ATP-sensitive K+ channels in afferent arterioles of rats with streptozotocin (STZ)-induced diabetes. The present study explored the hypothesis that other types of K+ channel also contribute to afferent arteriolar dilation in STZ rats. The in vitro blood-perfused juxtamedullary nephron technique was utilized to quantify afferent arteriolar lumen diameter responses to K+ channel blockers: 0.1-3.0 mM 4-aminopyridine (4-AP; KV channels), 10-100 microM barium (KIR channels), 1-100 nM tertiapin-Q (TPQ; Kir1.1 and Kir3.x subfamilies of KIR channels), 100 nM apamin (SKCa channels), and 1 mM tetraethylammonium (TEA; BKCa channels). In kidneys from normal rats, 4-AP, TEA, and Ba2+ reduced afferent diameter by 23 +/- 3, 8 +/- 4, and 18 +/- 2%, respectively, at the highest concentrations employed. Neither TPQ nor apamin significantly altered afferent diameter. In arterioles from STZ rats, a constrictor response to TPQ (22 +/- 4% decrease in diameter) emerged, and the response to Ba2+ was exaggerated (28 +/- 5% decrease in diameter). Responses to the other K+ channel blockers were similar to those observed in normal rats. Moreover, exposure to either TPQ or Ba2+ reversed the afferent arteriolar dilation characteristic of STZ rats. Acute surgical papillectomy did not alter the response to TPQ in arterioles from normal or STZ rats. We conclude that 1) KV, KIR, and BKCa channels tonically influence normal afferent arteriolar tone, 2) KIR channels (including Kir1.1 and/or Kir3.x) contribute to the afferent arteriolar dilation during diabetes, and 3) the dilator impact of Kir1.1/Kir3.x channels during diabetes is independent of solute delivery to the macula densa.
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