Evidence map›Paper›PMID 18495782›Full record

ReviewJournal of leukocyte biology2008

T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't.

Angela Dolganiuc, Gyongyi Szabo

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of leukocyte biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Tolerance--is it worth it?Cold Spring Harbor perspectives in medicine · 2014
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. NK cells, innate immunity and hepatitis C infection after liver transplantation.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011
    Review
  8. Review
  9. Viral vaccines and CTL response.Journal of biomedicine & biotechnology · 2010
    Review
  10. PD-1 tempers Tregs in chronic HCV infection.The Journal of clinical investigation · 2009
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Angela DolganiucDepartment of Medicine, University of Massachusetts Medical School, LRB 270J, 364 Plantation St., Worcester, MA 01605, USA. angela.dolganiuc@umassmed.edu
Gyongyi Szabo
University of Massachusetts Chan Medical School · US

Funding

Alcohol and Monocyte Signaling Administrative SupplementR01AA011576 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Gyongyi Szabo · 1998 to 2026
$9.3M
ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSIONR01AA008577 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SZABO, GYONGYI · 1995 to 2009
$3.5M
Alcohol disrupts TLR4 signaling in lipid raftsR21AA016571 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DOLGANIUC, ANGELA · 2007 to 2008
$427k
ETHANOLS ROLE IN MEDIATION OF MONOCYTE IMMUNOSUPPRESSIONR29AA008577 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SZABO, GYONGYI · 1990 to 1994
–
NIAAA NIH HHS AA008577NIAAA NIH HHS AA011576NIAAA NIH HHS AA016571NIAAA NIH HHS R01 AA008577NIAAA NIH HHS R01 AA011576NIAAA NIH HHS R21 AA016571NIAAA NIH HHS R29 AA008577
6 · The paper itself

Abstract

The mechanism behind the apparent lack of effective antiviral immune response in patients with chronic hepatitis C virus (HCV) infection is poorly understood. Although multiple levels of abnormalities have been identified in innate and adaptive immunity, it remains unclear if any of the subpopulations of T cells with regulatory capacity (Tregs) contribute to the induction and maintenance of HCV persistence. In this review, we summarize the current knowledge about Tregs as they relate to HCV infection.

Indexed as

AnimalsHepacivirusHepatitis CHumansImmunity, CellularT-Lymphocytes, RegulatoryViral Core ProteinsViral Core Proteins

Identifiers

PMID18495782
PMCPMC2516897
OpenAlexW2152982804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.