ArticleJournal of virology2008
Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- Triple Viral Infections in Advanced Breast Cancer: Insights from a Three-Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2024Article
- Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10Microbiome · 2023Article
- Intestinal Immune System and Amplification of Mouse Mammary Tumor Virus.Frontiers in cellular and infection microbiology · 2021Review
- Mouse cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells.Virology journal · 2014Article
- B-cell lymphopoiesis is regulated by cathepsin L.PloS one · 2013Article
- Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Regulatory T cells in infection.Advances in immunology · 2011Review
- Superantigens increase the survival of mice bearing T cell lymphomas by inducing apoptosis of neoplastic cells.PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Mouse mammary tumor virus (MMTV) is a milk-borne betaretrovirus that has developed strategies to exploit and subvert the host immune system. Here, we show in a natural model of MMTV infection that the virus causes early and progressive increases in superantigen (SAg)-specific Foxp3(+) regulatory T cells (T(reg)) in Peyer's patches (PP). These increases were shown to be dependent on the presence of dendritic cells. CD4(+) CD25(+) T cells from the PP of infected mice preferentially suppress the proliferative response of T cells to SAg-expressing antigen-presenting cells ex vivo. We investigated the influence of the depletion of CD25(+) cells at different stages of the infection. When CD25(+) cells were depleted before MMTV infection, an increase in the number of PP SAg-cognate Foxp3(-) T cells was found at day 6 of infection. Since the SAg response is associated with viral amplification, the possibility exists that T(reg) cells attenuate the increase in viral load at the beginning of the infection. In contrast, depletion of CD25(+) cells once the initial SAg response has developed caused a lower viral load, suggesting that at later stages T(reg) cells may favor viral persistence. Thus, our results indicated that T(reg) cells play an important and complex role during MMTV infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.